苄叉丙酮与芳香胺和芳香醛的Mannich反应

The Mannich reaction between benzalacetone aromatic aldehydes and aromatic amines

苄叉丙酮与芳香胺和芳香醛在０～２５℃和少量浓盐酸催化下能直接进行Ｍａｎｎｉｃｈ反应，生成了相应的Ｍａｎｎｉｃｈ碱（Ⅰ）———５芳基５芳胺基１苯基１戊烯３酮，产率为５４％～９３％，共合成了１４个新化合物．产物的结构经元素分析、１ＨＮＭＲ、ＩＲ和ＭＳ证实．还讨论了反应的适宜条件．

n the presence of small amount of concentrated hydrochloric acid,the Mannich reaction of benzalacetone,aromatic aldehydes and aromatic amines can take place directly at 0～25℃.Fourteen corresponding Mannich bases(Ⅰ),5 aryl 5 arylamino 1 phenyl 1 penten 3 one,were prepared with 54%～93% Yield.All of these Mannich bases(Ⅰ) were new compounds.These target compounds were verified by elemental analyses,IR, 1 HNMR,MS.The reaction conditions were also discused.