氟比洛芬酯对手术致痛大鼠行为学的影响

Effect of Flurbiprofen Axetil on Behavior of Rats with Incision-Induced Pain

目的观察氟比洛芬酯对手术致痛大鼠行为学的影响。方法将48只SD大鼠随机分为6组。对照1(D1)组大鼠单纯吸入异氟醚麻醉,不进行手术,其余5组(D2、K1～K4组)以异氟醚吸入使大鼠麻醉,按BRENNAN法手术,建立大鼠手术切口疼痛模型。20min后经尾静脉给药。D1组、D2组大鼠给予0.9%氯化钠注射液,K1～K4组分别给予氟比洛芬酯注射液2,4,8,16mg·kg-1。待大鼠手术清醒及每组给药后1h,进行累积疼痛评分,观察给药后反应。结果氟比洛芬酯可剂量依赖性地降低切口疼痛模型大鼠的累积疼痛评分(P<0.05)。结论氟比洛芬酯可抑制外科手术的疼痛反应,并呈一定的剂量依赖性。

Objective To study effect of flurbiprofen axetil on behavior of rats with incision-induced pain. Methods 48 250g-weight rats were randomly divided into 6 groups. The incision pain model in rats were established by the Brennan＇s method and anesthetized by breathing in isoflurane, except the control groupl （D1 group）without operation but anesthetized with isoflurane only. 20 m later, the control groupl and control group2 （D2 group） were injected with physiological saline by vena caudalis,the other 4 groups were injected with flurbiprofen axetil 2 mg.kg^-1 ,4 mg.kg^-1, 8 mg.kg^-1, 16 mg.kg^-1 （K1 , K2, K3, K4 group ）, respectively. The pain scores were calculated after rats came back to consciousness and 1 hour after injection. Results Flurhiprofen axetil decreased caleulative pain scores of rats with incision pain in a dose-dependent manner. Conclusion Administration of flurbiprofen axetil could close relatively suppress the incision-evoked nocieeptive behavior.