培哚普利联用胺碘酮在非瓣膜性房颤复律后维持窦性心律的观察

Clinical efficacy of perindopril combination therapy with amiodarone in patients with persistent non-valvular atrial fibrillation

目的评价血管紧张素转化酶抑制剂培哚普利联用胺碘酮在持续性非瓣膜性心房颤动转复后维持窦性心律的作用及对左心房功能的影响。方法将54例持续性非瓣膜性房颤患者药物或电复律后随机分为胺碘酮组(Ⅰ组,n=26)、胺碘酮加培哚普利组(Ⅱ组,n=28),治疗随访时间为1年,比较两组治疗后的窦性心律维持率以及治疗前、治疗后6个月、12个月的左心房内径。结果治疗12个月后,Ⅰ组左心房内径大于Ⅱ组(P<0.05)。Ⅰ组窦性心律的维持率明显低于Ⅱ组(P<0.05)。结论胺碘酮联用培哚普利在持续性非瓣膜性心房颤动转复后维持窦性心律优于单用胺碘酮,并能抑制左心房的扩大。

Objective To evaluate the clinical efficacy in angiotensin-converting enzyme inhibitor perindopril combination with amiodarone after the resumption of persistent non-valvular atrial fibrillation. Methods Fifty-four patients with persistent non-valvular atrial fibrillation were included in the study and randomly divided into two groups：group 1 （amiodarone group, n = 26）was treated with amiodarone alone,group 2（amiodarone plus perindopril group,n= 28） was treated with amiodarone and perindopril in combination. The duration of observation was up to one year. Comparing the sinus rhythm maintenance and the left atrial diameter （LAD） in two groups after treatment. Results After 12- month-treatment,the maintenance of sinus rhythm in group 2 was higher significantly than which in group 1. LAD in group 1 was significantly larger than group 2（P〈0.05）. Conclusion The results of this study suggest that the combination of amiodarone with angiotensin-converting enzyme inhibitor perindopril are more effective than amiodarone alone in sinus rhythm maintenance after the resumption of persistent non-valvular atrial fibrillation,and it can inhibit the enlargement of left atrium.