戊型肝炎病毒感染与胰腺癌发病的相关性临床分析

Clinical Analysis of Correlation Between Pancreatic Cancer and Hepatitis E Virus Infection

目的:分析戊型肝炎病毒(HEV)感染与胰腺癌发病的相关性。方法:以12例HEV感染的胰腺癌患者(感染组)和47例非HEV感染的胰腺癌患者(非感染组)为研究对象,收集相关临床资料包括胰腺、肝脏的病理表现等,分析HEV感染的胰腺癌患者的临床特征,并且用HEVRNA直接测序技术对合并HEV感染的胰腺癌患者的胰腺组织进行HEV定位分析。结果:感染组合并肝癌、肝硬化的概率高于非感染组,感染组胰腺癌发病的平均年龄较非感染组提前8.5年,2例HEV感染的胰腺癌患者的胰腺组织中检测到HEVORF2片段。结论:HEV感染与胰腺癌发病存在相关性。

Objective：To analyse the correlation between pancreatic cancer and hepatitis E virus（HEV）infection. Methods：The related clinical data containing 12 pancreatic cancer patients combined with HEV infection（infection group）and 47 pancreatic cancer patients （non-infection group）were collected. And HEV ORF2 segments in pancreas tissue of patients was detected by RNA direct sequencing technology. Results ：The incidence of liver cancer or/and liver cirrhosis was higher in infection group than that in non-infection group（P〈0.05）. HEV ORF2 segments were found in pancreas tissue of two patients in infection group. Conclusion：Highly statistically correlation was found between HEV infection and pancreatic cancer.