小剂量垂体后叶素合并硝酸甘油治疗咯血

Analysis of pituitrin with nitroglycerin on patients with hemoptysis

目的评价小剂量垂体后叶素联合硝酸甘油治疗咯血的疗效及不良反应。方法将50例咯血患者随机分为两组,治疗组在常规治疗基础上(n=26)应用小剂量垂体后叶素联合硝酸甘油;对照组(n=24)在常规治疗基础上仅应用小剂量垂体后叶素。分析其疗效及不良反应。结果48小时后治疗组有效率96.15%(25/26),对照组有效率58.33%(14/24),差异有统计学意义(P=0.012);治疗组对血压影响小,无统计学意义(P>0.05),对照组能引起血压升高的副作用(P<0.05);治疗组出现头晕头痛、胸闷、心悸、腹痛、腹泻、恶心呕吐、出汗、面色苍白等不良反应比对照组少,差异有统计学意义(P<0.05)。结论小剂量垂体后叶素联合硝酸甘油治疗中量咯血比垂体后叶素单药治疗中量咯血疗效明显提高,且能减少垂体后叶素不良反应。

Objective To assess the curative effect and adverse reactions of low dosage pituitrin together with nitroglycerin on the patients with hemoptTsis. Methods 50 cases of patients were randomized into the treatment group （ n = 26） and control group （ n = 24）. The treatment group received low dosage pituitrin together with nitroglycerin on the base of routine treatment, while the control group only received low dosage pituitrin. We evaluated the curative effect and adverse reactions. Results The total curative effect of the treatment group was significantly higher than that of the control group after 48 hours. The total effective rates were 96.15% （25/26） in the treatment group, while 58. 33% （14/24） in the control group （P =0.012）. The blood pressure didn＇t increase in the treatment group （P 〉 0. 05 ）, while it increased in the control group （ P 〈 0. 05 ）. The attendance of dizziness, headache, stuffiness, palpitation, abdomen ache, diarrhea, nausea, vomiting, diaphoresis and pale was significantly less than that in the control group （ P 〈 0. 05 ）. Conduction Low dosage pituitrin together with nitroglycerin is more effective than single pituitrin in treating moderate hemoptysis, and it decreases the adverse reactions.