地塞米松对多囊卵巢综合征促排卵治疗效果的影响

Clinical analysis of the effects of dexamethasone on ovulation induction in polycystic ovary syndrome

目的探讨地塞米松对多囊卵巢综合征（PCOS）促排卵治疗效果的影响。方法将68例PCOS不孕患者随机分为治疗组34例（应用地塞米松配合促排卵药物）和对照组34例（单独应用促排卵药物），检测两组治疗前后血清雄激素（T），黄体生成素（LH）、卵泡刺激素（FSH），卵泡平均生长率及体重指数（BMI）的变化，比较两组排卵率及妊娠率。结果治疗组血清T值较治疗前下降（P〈0．01），对照组治疗前后血清T值差异无统计学意义（P〉0．05）；两组治疗后血清LH较治疗前均下降（P〈0．01），血清FSH较治疗前差异均无统计学意义（P〉0．05）；两组治疗后的卵泡生长率较治疗前差异均有统计学意义（P〈0．01）；两组治疗前后BMI差异均无统计学意义（P〉0．05）；治疗组的排卵率高于对照组（P〈0．05），妊娠率与对照组相比较差异无统计学意义（P〉0．05）。结论地塞米松能降低PCOS患者血清T，对促排卵治疗能产生有利影响。

Objective To explore the effects of dexamethasone on ovulation induction in polycystic ovary syndrome （PCOS）. Methods This clinical study included 68 women with PCOS, which of them were divided into two groups： 34 in dexamethasone treating（ dexamethasone combined with ovulation induction） and 34 in con- trol（ ovulation induction treatment only）. Subsequently, comparisons were made between pre and after drug treat- ment in two groups, the main indexes were the levels of testosterone（ T）, luteinizing hormone（ LH）, follicle stim- ulating hormone（FSH） , growth rate of follicle, and body mass index（BMI）. And we have also considered the ovulation rate and pregnancy rate, and compared these indexes in dexamethasone treating group with control group. Results There were significant differences between pre and after dexamethasone treatment in the levels of T in treatment group（ P 〈 0. 01 ） , and there were not significant differences between pre and after treatment in the lev- els of T in control group （ P 〉 0.05 ）. LH had decreased significantly after treatment in both two groups （ P 〈 0. 01 ） , FSH had not significant differences between pre and after treatment in two groups（ P 〉 0.05 ）. The growth rate of follicle of two groups had elevated after treatment （ P 〈 0.01 ）. And the ovulation rate in dexamethasone treating group was higher than that in control group（P 〈 0.05 ）, but there were not significant differences between the two groups in the clinical pregnancy rates（ P 〉0.05 ）. There were not significant differences between pre and after treatment in the levels of BMI in both two groups （ P 〉 0.05 ）. Conclusions Dexamethasone can decrease the T in plasm levels. It is good for ovulation induction in PCOS.