肝细胞癌非手术治疗的现状和进展

Current status and progress in non-resection therapies for hepatocellular carcinoma

在过去的20多年中,肝细胞癌(hepatocellular carcinoma,HCC)的诊断和治疗有了显著提高,但仍具有早期诊断难、发展快、恶性程度高、预后差的临床特点。手术切除一直被认为是可能治愈HCC的惟一方法。但70%～80%的患者确诊HCC时已为中晚期,无手术切除时机。对不能手术切除的HCC患者,近年发展的非手术治疗技术可延缓甚至控制肿瘤生长,延长生存期,提高生活质量。本文对HCC非手术治疗现状和进展进行综述。

In the past two decades, there have been great improvements in the diagnosis and treatment of hepatocellular carcinoma （HCC）, but the problems, including difficult diagnosis at early stage, quick progression, high malignancy and poor prognosis remain to be unsolved. Surgical resection is the mainstay of treatment for HCC. But 70%-80% of HCC patients are diagnosed in an advanced stage when most potentially curative therapies, such as surgical resection, are not eligible to be conducted. In recent years, non-resection therapies for unresectable HCC have been developed, which can control tumor growth, prolong survival time and improve quality of life. This review covers the current status and progress of non-resection therapies for HCC.