摘要
目的观察六味五灵片治疗酒精性肝炎(alcoholic steatohepatitis,ASH)的临床疗效。方法68例ASH患者随机分为2组。治疗组36例,口服六味五灵片3片(3/d),第4个月为3片(2/d),第5个月为2片(2/d),第6个月为2片(1/d),对照组32例,口服硫普罗宁片200mg(3/d),疗程均为24周。结果与治疗前比较,治疗24周后治疗组及对照组在ALT、AST、ALP、GGT、TC、TG水平下降和B超影像学改善方面差异均有统计学意义(P<0.01)。以上指标进行组间比较,在ALT、AST、ALP、GGT水平下降及B超影像学改善方面,治疗组优于对照组,差异均具有统计学意义(P<0.05),而TC、TG水平下降在2组间差异无统计学意义(P>0.05)。结论六味五灵片及硫普罗宁片治疗ASH在以上观察指标均有改善;在ALT、AST、ALP、GGT水平下降及B超影像学改善方面,六味五灵片均优于硫普罗宁片。
Objective To investigate the effect of Liuweiwuling tablet on alcoholic steatohepatitis (ASH). Methods A total of 68 patients with ASH were randomly divided into two groups. The treatment group (n=36) was given Liuweiwuling tablet, 3 tablets thrice a day in 3 months, 3 tablets twice a day in the 4th month, 2 tablets twice a day in the 5th month, and 2 tablets once a day from the 6th month to the end of the treatment. The control group (n=32) was given tiopronin tablet, 200 mg thrice a day. Both groups were treated for 24 weeks. Results Compared with pretherapy, the levels of ALT, AST, ALP, GGT, TC, TG and the improvement in ultrasonic B-mode imaging in both groups were statistically different after 24 weeks of treatment (P〈0.01). The differences in the levels of ALT, AST, ALP, GGT and in the improvement in ultrasonic B-mode imaging were statistically significant between both groups (P〈0.05), while the diffe- rences in the levels of TC and TG were not statistically significant (P〉0.05). Conclusions Both Liuweiwuling tablet and tiopronin tablet can improve the blood biochemical parameters and ultrasonic B-mode imaging in the treatment of ASH. Liuweiwuling tablet is more effective than tiopronin tablet in the decrease in the levels of ALT, AST, ALP, GGT, and in the improvement in ultrasonic B-mode imaging.
出处
《传染病信息》
2009年第2期107-109,共3页
Infectious Disease Information
关键词
酒精性肝炎
六味五灵片
硫普罗宁片
alcoholicsteatohepatitis
Liuweiwulingtablet
tiopronintablet