葡萄糖转运蛋白1在胃癌组织及转移淋巴结中的表达及其与预后的关系

Expression of glucose transporter 1 in gastric carcinoma and metastatic lymph nodes and its association with prognosis

目的研究葡萄糖转运蛋白1（GLUT1）在胃癌组织及转移淋巴结中的表达特点，探讨其与肿瘤生物学特征和患者预后之间的关系。方法采用免疫组织化学方法对79例胃癌组织及癌旁正常胃组织GLUT1表达特征进行分析.并分析其预后与GLUT1表达的关系。结果高、中、低分化腺癌患者GLUT1表达阳性率分别为56.5％、33.3％和36.0％；黏液腺癌和印戒细胞癌GLUT1表达阳性率分别为1／6和7.7％（1／13）。GLUT1表达阳性率与肿瘤最大直径（P〈0.01）、有无淋巴结转移（P=0.032）和胃癌临床分期（P=0.007）等因素相关。转移淋巴结GLUT1阳性表达率为12.6％。GLUT1阳性组和阴性组1年生存率分别为64.3％和90.2％（P=0.035）。结论GLUT1表达与胃癌的侵袭性指标相关，可能是胃癌预后不良的一个标志。

Objective To examine the expression and distribution of glucose transporter 1 （GLUT1） in gastric cancer tissues and investigate its relation to clinicopathological parameters and prognosis of patients with gastric carcinoma. Methods Immunohistochemistry was used to examine the expression of GLUT1 in 79 samples of gastric carcinoma tissue. The association of GLUT1 expressive features with clinicopathological characteristics, including histological subtype, depth of invasion, lymph node metastasis, and patients＇ prognosis were analyzed. Results None of normal gastric epithelium expressed GLUT1, whereas 28 of 79 carcinoma samples（35.4%） were positive. Well differentiation type, median differentiation type and poorly differentiation type were GLUT1 positive in 56.5%, 33.3%, and 36.0% cases respectively, while the Signet ring cell carcinoma and mutinous ad were rarely positive （1/6 and 7.7%, respectively）. GLUT1 positivity was associated with histological subtype （P=0.044）, tumor size （P〈0.01）, lymph node metastasis （P=0.032）, and carcinoma stage （P=0.007）. One year survival rates of patients with GLUY1 positive and negative were 64.3% and 90.2% respectively （P=0.035）. Conclusion In human gastric carcinoma, GLUT1 expression is associated with tumor aggressiveness, and may be a useful marker of prognosis.