垂体促性腺激素瘤的临床分析

Clinical analysis of pituitary gonadotropinoma

目的探讨垂体促性腺激素瘤的临床特点。方法对72例免疫组织化学诊断为垂体促性腺激素瘤患者进行回顾性分析。结果发病以40～60岁男性多见。临床表现以肿瘤压迫症状为主，性腺功能异常的表现不多见。免疫组织化学均为促性腺激素卵泡刺激素（FSH）和（或）黄体生成素（LH）阳性，以FSH阳性多见，伴催乳素（PRL）和促甲状腺激素（TSH）阳性各1例，但均无相应的临床表现。病理诊断多数为促性腺激素腺瘤。治疗以手术为主，首选经蝶骨手术。结论免疫组织化学是目前诊断促性腺激素瘤的最可靠的方法，以FSH阳性为主。免疫组化特征与临床表现的关联不大。治疗以经蝶骨手术为主。

Objective To explore the clinical characteristics of pituitary gonadotropinoma. Methods A total of 72 patients with pituitary gonadotropinoma diagnosed using immunohistochemistry method were retrospectively analyzed. Results Gonadotropinoma was often occurred in 40 - 60 years old men. Tumor suppression symptom was the predominant clinical manifestation and gonad function abnormality was not seen frequently. Immunohistochemistry characteristics was FSH and/or LH positive with one being PRL and TSH positive respectively. Majority was FSH positive. All patients had not corresponding clinical manifestation. Pathological diagnosis was gonadotropinoma mostly. Surgery was the main therapy method and transsphenoidal surgery was chief choice. Conclusions Immunohistochemistry is the most reliable method of diagnosing gonadotropinoma and majority is FSH positive. The manifestation of immunohistochemistry was not often associated with clinical manifestation. Transsphenoidal surgery is the main therapy method.