CYP2J2基因和EPHX2基因多态性与肺癌易感性研究

Polymorphism s of CYP2J2 and EPHX2 genes and genetic susceptibility of Lung cancer

目的探讨CYP2J2基因启动子区G-50T多态性和EPHX2基因G860A多态性与肺癌发生的关系。方法经病理检查确诊为肺癌患者150例（肺癌组），300名本院健康体检者作为对照组，检测其CYP2J2基因启动子区G-50T多态性和EPHX2基因G860A多态性，并进行统计学分析。结果肺癌组和对照组比较，CYP2J2启动子区G-50T多态性差异无统计学意义，而肺癌组患者EPHX2 860G等位基因频率显著高于对照组人群（96％比78．3％，P〈0．01），多元回归分析方法显示，肺癌的发生与EPHX2 G860A多态性显著相关（校正OR值=0．164，95％CI 0．079～0．342，P〈0．001）。结论EPHX2 G860A多态件与肺痛密切相关．可作为肺癌高毹患者的预涮指标．

Objective To investigate the association between the CYP2J2 gene G-50T and EPHX2 gene G860A polymorphism and lung cancer. Methods One hundred and fifty patients with lung cancer and 300 healthy people as control group were collected. The CYP2J2 gene G-50T and EPHX2 gene G860A polymorphisms were detected and analyzed. Results The allele frequency of EPHX2 gene 860 G in patients with lung cancer was significantly higher than that in control group （96% vs 78.3%, P 〈 0. 01 ）. Logistic regression analysis showed that EPHX2 gene G860A polymorphisms was associated to lung cancer significantly（ adjusted OR ：0. 164,95% CI 0.079 - 0.1342 ,P 〈 0.001 ）. However, there was no significantly association between CYP2J2 gene G-50T polymorphism and lung cancer. Conclusion EPHX2 gene G860A polymorphism is associated with long cancer, which could become a predictor of lung cancer in high risk population.