期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肿瘤坏死因子α在2型糖尿病胰岛素抵抗中的作用 被引量：3

原文传递
导出
摘要 肿瘤坏死因子α(TNF-α)是一种具有多种生物学功能的细胞因子,它在脂肪组织中的过度表达是肥胖相关2型糖尿病(T2DM)发生胰岛素抵抗(IR)的中心环节。本文综述了TNF-α在T2DM胰岛素抵抗中的作用机制,以及TNF-α的基因多态性对T2DM胰岛素抵抗的影响。
作者 沈玉洁 吴升华
机构地区 南京医科大学第一临床医学院 南京医科大学第一附属医院儿科
出处 《江苏医药》 CAS CSCD 北大核心 2009年第5期582-583,共2页 Jiangsu Medical Journal
关键词 糖尿病胰岛素抵抗 肿瘤坏死因子Α 2型糖尿病 TNF-Α T2DM 生物学功能 基因多态性 细胞因子
分类号 R587.1 [医药卫生—内分泌] R285.5 [医药卫生—中药学]
  • 相关文献

参考文献19

  • 1Borst SE. The role of TNF-α in insulin resistance[J]. Endocrine, 2004,23 (2-3): 177-182.
  • 2Kershaw EE, Flier JS. Adipose tissue as an endocrine organ [J]. J Clin Endocrinol Metah,2004,89(6) :2548-2556.
  • 3Mishima Y, Kuyama A, Tada A, et al. Relationship between serum tumor necrosis factor-α and insulin resistance in obese men with type 2 diabetes mellitus[J]. Diabetes Res Clin Pract, 2001,52(2) : 119-123.
  • 4Good M,'Newell FM, Haupt LM, et al. TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue-influence of BMI and adipose distribution[J]. Diab Vasc Dis Res, 2006,3 (1) : 26-33.
  • 5Carey AL,Febbraio MA. Interleukin-6 and insulin sensitivity: friend or foe[J]? Diabetologia, 2004,47(7) : 1135-1142.
  • 6Dominguez H,Storgaard H, Rask-Madsen C, et al. Metabolic and vascular effects of tumor necrosis factor-α blockade with etanercept in obese patients with type 2 diabetes[J]. J Vasc Res, 2005,42 (6): 517-525.
  • 7Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes[J]. Diabetes Care, 2004, 27(3) :813-823.
  • 8Gupta A, Ten S, Anhalt H. Serum levels of soluble tumor necrosis factor-α receptor 2 are linked to insulin resistance and glucose intolerance in children [J]. J Pediatr Endocrinol Metab, 2005,18 (1) : 75-82.
  • 9Facchini FS, Hua NW, Stoohs RA. Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of non- alcoholic fatty liver disease[J]. Gastroenterology, 2002, 122 (4) : 931-939.
  • 10Ruan H, Lodish HF. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α [J]. Cytokine Growth Factor Rev, 2003,14(5) : 447-455.

二级参考文献10

  • 1韩睿,田浩明,童南伟,冉兴无,赵桂芝.2型糖尿病患者性别、肥胖对血中瘦素、神经肽Y和TNF-α的影响[J].中国糖尿病杂志,2006,14(1):18-19. 被引量：2
  • 2Bray GA.Medical consequences of obesity[J].J Clin Endocrinol Metab,2004,89(6):2 583
  • 3Borst SE.The role of TNF-alpha in insulin resistance[J].Endocrine,2004,23(2/3):177
  • 4Uysal KT,Wiesbrack SM,Marino MW,et al.Protection from obesity-induced insulin resistance in mice laeking TNF-α function[J].Nature,1997,389(6 651):610
  • 5Kim JA,Yeh DC,Ver M,et al.Phosphorylation of ser24 in the plecktrin homology domain of insulin receptor substrate-a by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase:crosstalk between inflammatory signaling and insulin signaling that may contribute to insulin resistance[J].J Biol Chem,2005,280(24):23173
  • 6Kubaszek A,Pihlajamaki J,Komarovski V,et al.Promoter polymorphism of the TNF(G-308A)and IL-6(C-174G)gene predict the promoter from impaired glucose tolerance to type 2 diabetes[J].Diabetes,2003,52(7):1 872
  • 7Bertin E,Nguyen P,Guenounon M,et al.Plasma levels of tumor necrosis factor-alpha(TNF-alpha)are essentially dependent on visceral fat amount in type 2 diabetic patients[J].Diabetes Metab,2000,26(3):178
  • 8Philip A,Subramanian R,Chunling L,et al.Adipose tissue tumor necrosis factor and interleukin-6,expression in obesity and insulin resistance[J].Am J Physiol Endocrinoln Metab,2001,280(5):E745
  • 9Dominguez H,Storgaard H,Rask-Madsen C,et al.Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes[J].J Vasc Res,2005,42(6):517
  • 10贾少丹 ,王颜刚 .肿瘤坏死因子-α与胰岛素抵抗[J].辽宁实用糖尿病杂志,2004,12(1):50-52. 被引量：8

共引文献16

同被引文献33

引证文献3

二级引证文献26

江苏医药
2009年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部