盐酸普罗帕酮的合成

Synthesis of Propafenone Hydrochloride

苯酚和乙酸酐经酯化、重排、与苯甲醛缩合和催化还原得到2′-羟基二氢查尔酮,再经由环氧氯丙烷醚化、正丙胺胺化、盐酸成盐得到盐酸普罗帕酮,总收率为25%。

Propafenone hydrochloride was synthesized from phenol and acetic anhydride by esterification, Fries rearrangement, condensation with benzaldehyde and catalytic reduction to give 2＇-hydroxydihydrochalcone, which was subjected to etherification with epichlorohydrin, amination with n-propylamine and HC1 salt formation with an overall yield of 25 %.