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假单胞菌X1的培养及哌嗪-2-甲酰胺的拆分条件优化 被引量：2

Optimization of Culture Conditions of Pseudomonas sp. X1 and Resolution of Piperazine-2-carboxaminde
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摘要 采用单因素和正交试验,优化假单胞菌(Pseudomonas sp.)X1的培养基组成及培养条件,并建立了该菌株拆分(R/S)-哌嗪-2-甲酰胺生产(S)-哌嗪-2-羧酸的条件,总得率为90.2%,R型和S型产物的ee值为98.6%和99.2%。 The optimal culture conditions and medium composition of Pseudomonas sp. X1 were obtained by single factors and orthogonal experiment. The conditions of the resolution of piperazine-2-carboxamide to （S）- piperazine-2-carboxylic acid were also improved. The total recovery of the two enantiomer derivatives is 90.2 %, and the ee values of R- and S-products are 98.6% and 99.2%.
作者 吕志堂 徐长源 郭晓东 张秀敏
机构地区 河北大学生命科学学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2009年第5期341-344,共4页 Chinese Journal of Pharmaceuticals
基金 河北省自然科学基金资助项目(C2008000598)
关键词 (S)-哌嗪-2-羧酸 假单胞菌 培养 拆分 （S）-piperazine-2-carboxylic acid Pseudomonas sp. culture resolution
分类号 Q939.9 [生物学—微生物学]
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同被引文献65

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中国医药工业杂志
2009年 第5期

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