冠状动脉支架置入术对冠心病患者术后早期血清抵抗素水平的影响

Effect of coronary stenting on serum resistin levels

目的评价经皮冠状动脉支架置入术(CSI)对血清抵抗素水平的影响。方法选择2007年7月至2008年5月在我院行CSI的40例患者为研究对象(CSI组),同时选择一组同期进行冠状动脉造影(CAG)的40例患者作为对照(CAG组)。采用酶联免疫(ELISA)法检测血清抵抗素和超敏C反应蛋白(Hs-CRP)含量,并分别于CSI或CAG术前及术后1 h、6 h、24 h采集静脉血进行血清抵抗素和Hs-CRP含量的测定。结果CSI组患者血清抵抗素水平术后6 h显著高于术前(30.4±9.2μg/L比23.4±6.4μg/L,t=9.03,P<0.01),术后24 h Hs-CRP含量显著高于术前(15.2±4.1 mg/L比7.4±3.4 mg/L,P<0.01),并达到高峰。CAG组患者造影后与造影前比较,血清抵抗素水平差异无统计学意义(P>0.05)。结论冠状动脉支架置入术后血清抵抗素水平升高,提示术后有炎症刺激反应。

Objective To investigate the serum levels of resistin after coronary stent implantation （CSI）. Methods Forty patients who underwent coronary stenting were included in this study and another 40 patients who received coronary angiography during the same period were selected as control The concentration of resistin and high-sensitivity C-reactive protein （Hs-CRP） was measured by enzyme-linked immunosorbent assay （ELISA）. Blood samples for measurement of resistin and Hs-CRP were taken right before the procedure and at 1 h, 6 h and 24 h after the procedure . Results The serum resistin level measured at 6 hr after the procedure in patients who had received PCI was higher than that before the procedure （30.4：1：9. 2 ixg/L vs 23.4 ：!：6. 4 p,g/L,t =9.03, P 〈0. 01 ）. The Hs-CRP level reached its peak 24 hrs after the procedure in patients undergone PCI and was significantly higher than that before the procedure （ 15.2±4. 1 mg/L vs 7.4± 3.4 mg/L,P 〈0. 01 ）. The resistin levels of patients who only had CAG showed no significant changes before and after the procedure （ P 〉 0. 05 ）. Conclusion Coronary stenting causes a detectable increase in serum levels of resistin and it can be regarded as an indicator for injury＇ caused by coronary stenting .