激光周边虹膜成形术治疗原发性闭角型青光眼急性发作的临床观察

Observe the clinical effect of acute attack of primary angle-closure glaucoma terated by laser peripheral iridoplasty

目的探讨激光周边虹膜成形术，作为原发性闭角型青光眼急性发作期首选治疗的疗效。方法非随机回顾性系列病例研究。对2007年7月至2008年7月确诊为原发性闭角型青光眼急性发作期患者，按是否行激光周边虹膜成形术，分为药物组及激光组，对其临床资料进行回顾性分析，包括眼压降至21mmHg（1mmHg=0．133kPa）以下所用的时间、甘露醇用量。结果眼压降至21mmHg以下所用时间，药物组为5-24h，平均10．67h；激光组为1～6h，平均3．08h，差异有统计学意义（t=4．359，P〈0．05）。甘露醇用量，药物组为250，750ml，平均437．5ml；激光组为125～375ml，平均218ml，差异有统计学意义（t=3．597，P〈0．05）。结论激光周边虹膜成形术治疗原发性闭角型青光眼急性发作是快速、有效和安全的，可以作为首选治疗方法。

Objective To evaluate the curative effect of laser peripheral iridoplasty as an initial treatment for acute attack of primary angle-closure glaucoma.Methods Non-randomized retrospective series of case studies.The acute attack of primary angle-closure glaucoma patients diagnosed with from July 2007 to July 2008 were divided into drug group and laser group according to whether used laser peripheral iridoplasty.Their clinical data were retrospective analyzed including the time of intraocular pressure decreased to 21mmHg （1mmHg=0.133kPa）,the amount used of mannitol.Results The time used to lower the IOP to 21mmHg： drug group needed 5-24 hours, average 10.67 hours, while laser group needed 1-6 hours, average 3.08 hours. There was a statistical significant difference（ t =4.359, P 〈 0.05 ）.The amount Of mannitol used：drug group was 250 -750 rnl, average 437.5ml, while laser group was 125-375 ml, average 218 ml.There was a statistical significant difference （ t =3.597, P 〈0.05 ）.Conclusion Laser peripheral iridoplasty appears to be very quick, effective and safe in treating acute attack of primary angle-closure glaucoma patients.It can be applied as an initial treatment of it.