期刊文献+

干扰素中和抗体对干扰素治疗慢性乙型肝炎效果的影响 被引量:2

Effect of interferon neutralization antibody in the treatment of chronic hepatitis B with interferon
原文传递
导出
摘要 在慢性病毒性肝炎治疗中,正广泛应用干扰素,并取得了较好的疗效,但仍有相当部分患者无应答,影响干扰素抗病毒疗效的因素很多,干扰素抗体的作用也是因素之一。在干扰素治疗慢性病毒性肝炎的过程中,干扰素能刺激机体产生干扰素中和抗体,为了探讨中和抗体的产生率及其临床意义,我们采用中和生物法检测了接受干扰素治疗的慢性乙型肝炎患者血清干扰素中和抗体,探讨了干扰素中和抗体对干扰素疗效的影响。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2009年第5期385-386,共2页 Chinese Journal of Hepatology
关键词 肝炎 乙型 慢性 干扰素 中和抗体 Hepatitis B, chronic Interferon Neutralization antibody
  • 相关文献

参考文献8

二级参考文献20

  • 1赵鸿,王贵强,韩忠厚,于敏,王玉华,孙谢文,于岩岩,王勤环,斯崇文,田庚善,韩祥云.动态观察血清HBV-DNA水平预测干扰素治疗慢性乙型肝炎疗效的意义[J].中华实验和临床病毒学杂志,2005,19(1):19-21. 被引量:18
  • 2Biron CA. Interferons alpha and beta as immune regulators -a newlook. Immunity, 2001, 14:661-664.
  • 3Kotenko SV, Gallagher G, Baurin VV, et al. IFN-lambdas mediate antiviral protection through a distinct class Ⅱ cytokine receptor complex. Nat Immunol, 2003, 4:69-77.
  • 4Platanias LC. Mechanisms of type- Ⅰ -and type- Ⅱ -interferonmediated signalling. Nat Rev Immunol, 2005, 5:375-386.
  • 5Maxwell BL, Talpaz M, Gutterman JU. Down-regulation of peripheral blood cell interferon receptors in chronic myelogenous leukemia patients undergoing human interferon (HuIFNalpha) therapy. Int J Cancer, 1985, 36:23-28.
  • 6Nakajima S, Kuroki T, Shintani M, et al. Changes in interferon receptors on peripheral blood mononuclear cells from patients with chronic hepatitis B being treated with interferon.Hepatology, 1990, 12 : 1261-1265.
  • 7Fierlbeck G, Ulmer A, Schreiner T, et al. Pharmacodynamics of recombinant IFN-beta during long-term treatment of malignant melanoma. J Interferon Cytokine Res, 1996, 16:777-781.
  • 8Kumar KG, Tang W, Ravindranath AK, et al. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J, 2003, 22: 5480-5490.
  • 9Yatsuhashi H, Fujino T, Matsumoto T, et al. Immunohistochemical analysis of hepatic interferon alpha-beta receptor level: relationship between receptor expression and response to interferon therapy in patients with chronic hepatitis C. J Hepatol, 1999, 30:995-1003.
  • 10Fujiwara D, Hino K, Yamaguchi Y, et al. Type Ⅰ interferon receptor and response to interferon therapy in chronic hepatitis C patients: a prospective study. J Viral Hepat, 2004, 11: 136-140.

共引文献14011

同被引文献15

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部