期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细胞周期调控在HT29结肠癌细胞低剂量辐射超敏感性中作用的研究 被引量：2

原文传递
导出
摘要 低剂量辐射超敏感性是细胞对低剂量照射（0．02～0．50Gy）较敏感，但对其后剂量区域（0．50～1．00Gy）敏感性下降。其发生机制现不清楚，可能与细胞周期调控有关^[1-2]。笔者观察HT29结肠癌细胞放射敏感性与1线照射剂量关系，分析不同剂量照射后细胞周期调控变化及Phos—pho—Cdc25C（Ser216）蛋白表达情况，探讨低剂量辐射超敏感性机制。
作者 陈俊妮 程晶 吴红革 薛军 曹文淼
机构地区 华中科技大学同济医学院附属协和医院肿瘤中心
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2009年第3期204-205,共2页 Chinese Journal of Radiation Oncology
基金 湖北省卫生厅科研基金资助项目（JX2ALL）
关键词 细胞周期调控 低剂量辐射 结肠癌细胞 超敏感性 HT29 低剂量照射 细胞放射敏感性 剂量关系
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献8

  • 1Marples B, Wouters BG, Joiner MC. An association between the radiation-induced arrest of G2-phase cells and low-dose hyper-radiosensitivity: a plausible underlying mechanism? Radiat Res,2003, 160 : 38-45.
  • 2Xiao HH, Makevev Y, Butler J, et al. 7-Hydroxystaurosporine ( UCN-01 ) preferentially sensitizes ceils with a disrupted TP53 to gamma radiation in lung cancer cell lines. Radiat Res,2002,158: 84-93.
  • 3欧广飞,王绿化,杨伟志.低剂量超敏感性在分次放射治疗中的意义[J].中华放射肿瘤学杂志,2003,12(1):40-45. 被引量：6
  • 4Krueger SA, Collis S J, Joiner MC, et al. Transition in survival from low dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity. Int J Radiat Oncol Biol Phys ,2007,69 : 1262-1271.
  • 5Thomas C, Charrier J, Massart C, et al. Low-dose hyper-radiosensitivity of progressive and regressive cells isolated from a rat colon tumour : impact of DNA repair. Int J Radiat Biol, 2008,84 : 533- 548.
  • 6Marples B, Joiner MC, Cann NE, et al. Evidence for the involvement of DNA-dependent protein kinase in the phenomena of low dose hyper-radiosensitivity and increased radioresistance. Int J Radiat Biol,2002,78 : 1139-1147.
  • 7Joiner MC ,Johns H. Renal damage in the mouse: the response to very small doses per fraction. Radiat Res,1988,114:385-398.
  • 8Wouters BG, Skarsgard LD. Low-dose radiation sensitivity and induced radioresistance to cell killing in HT 29 Cells is distinct from the'adaptive response'and cannot be explained by a supopulation of sensitive ceils. Radiat Res, 1997,148:435-442.

共引文献5

同被引文献52

  • 1金晓东,李强,郭传玲,郝冀芳,王菊芳,李文建,闫铮,戴中颖.利用超分次技术进行肿瘤治疗的探讨[J].原子核物理评论,2006,23(2):242-245. 被引量：3
  • 2Marples B. Is low-dose hyper-radiosensitivity a measure of G2- phase cell radiosensitivity? Cancer M.etast Rev,2004,23 (3-4) : 197-207.
  • 3Marples B, Wouters BG, Collis SJ, et al. Low-dose hyper- radiosensitivity:a consequence of ineffective cell cycle arrest of radiation damaged G2-phase ceils. Radiat Res, 2004,161 ( 3 ) : 247-255.
  • 4Marples B, Wouters BG, Joiner MC. An association between the radiation-induced arrest of G2-phase ceils and low-dose hyper- radiosensitivity : a plausible underlying mechanism? Radiat Res, 2003,160( 1 ) :38-45.
  • 5Krueger SA, Collis SJ, Joiner MC, et al. Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM SER 1981 activity. Int J Radiat Oncol Biol Phys,2007,69 (4) : 1262-1271.
  • 6Fernet M, Megnin-Chanet F, Hall J, et al. Control of the C2/M checkpoints after exposure to low doses of ionising radiation: implications for hyper-radioscnsitivity. DNA Repair ( Amst ), 2010,9( 1 ) :48-57.
  • 7Enns L, Bogen KT, Wizniak J, et al. Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis. Mol Cancer Res, 2004, 2 (10) :557-566.
  • 8Simonsson M, Qvarnstrem F, Nyman J, et al. Low-dose hypersensitive ,H2AX response and infrequent apoptosis in epidermis from radiotherapy patients. Radiother Oneol,2008,88 (3) :388-397.
  • 9Marples B, Joiner MC. Modification of survival by DNA repair modifiers: a probable explanation for the phenomenon of increased radioresistance. Int J Radiat Biol, 2000, 76 ( 3 ) : 305-312.
  • 10Krueger SA, Joiner MC, Weinfeld M, et al. Role of apoptosis in low-dose hyper-radiosensitivity. Radiat Res, 2007, 167 ( 3 ) : 260-267.

引证文献2

二级引证文献1

中华放射肿瘤学杂志
2009年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部