摘要
系统性硬皮病致病机制仍未明确，表观遗传学的迅速发展为解释遗传与环境因素共同作用的多基因疾病提供了有力的理论工具。近年来，系统性硬皮病相关研究在表观遗传学方面，尤其在DNA甲基化与RNA干扰方面，取得显著进展，为进一步探讨系统性硬皮病的发病机制以及深入治疗研究提供线索。
The pathogenesis of systemic sclerosis is still unanswered. Rapid development of epigenetics has provided a powerful theoretical tool for the elucidation of genetic and environmental factors affecting multigenic diseases. A significant progress has been achieved in recent epigenetic researches on systemic sclerosis, especially in the field of DNA methylation and RNA interference, which may benefit further research in the pathogenesis and treatment of systemic sclerosis.
出处
《国际皮肤性病学杂志》
2009年第3期150-152,共3页
International Journal of Dermatology and Venereology
