期刊文献+

中药消癌平联合奥宁、强的松治疗耄耋年龄淋巴瘤的设计与临床应用的前瞻性研究报告 被引量:1

A Report on Prospective Study of Design and Clinical Application of Senile Lymphoma with Xiaoaiping,Octretide Acetate and Prednisone
原文传递
导出
摘要 目的:观察消癌平联合奥宁、强的松治疗耄耋年龄淋巴瘤的疗效。方法:3名年龄大于80岁的老年淋巴瘤患者,不能接受化疗,血生化、血常规检查基本正常,治疗方法:消癌平60ml+5%葡萄糖液250ml,持续静脉滴注16天,奥宁0.8mg+生理盐水100ml,Civ(连续静脉泵入),(2ml/小时/48小时)×8次(16天);强的松片40mg,连续口服14天。按实体瘤近期疗效标准评价疗效。结果:总疗效CR1例,PR2例。3例患者中有2例目前仍存活,生活能自理。一例骨浸润伴骨破坏者,治疗后骨缺损稳定2个月以上无变化,但在CR后2个月进行巩固治疗期间发现脑浸润;一例患者在首次治疗期间发现脑浸润,经治疗后病灶稳定、无变化;另外一例患者在5次治疗出院后,因糖尿病诱发酮症酸中毒、昏迷、肺部感染,死亡。治疗期间除2例伴发糖尿病患者血糖增加外,几乎未见任何副作用。结论:消癌平、生长抑素类似物--奥宁、强的松联合应用,可能是治疗老年淋巴瘤的有效的治疗方法,但该方法不能扼制脑浸润的发生,对脑浸润也无确切的治疗效果。 Objective: To observe the curative effect of Xiaoaiping, Octretide Acetate and Prednisone on senile lymphoma. Meth- otis: 3 patients with lymphoma ,aged more than 80 years and not accepting chemotherapy and with fundamental normal blood routine and biochemistry tests,were given Xiaoaiping 60m1+5% Glucose injection 250ml, ivgtt,qd for 16 days; Octretide Acetate 0.8mg+ physiological saline 100ml, Civ(continue intervenous) (2ml/h/48h)× 8(16 days); and Prednisone tablets 40mg( per os for 14 days).Evaluate the curative effect according to the evaluation criteria in solid tumor. Results: 1 patient in CR,2 of PR .2 in these 3 patients still survive at present and could take care of themselves, one patient with bone infiltration and destruction ;after treatment there was no changes in bone destrction in more than 2 months, But in the stage 2 months later than CR ,we discovered brain invasion; 1 patient with brain invasion in the first therapy stage, and no changes in the focus after treatment; another patient died after 5 treatments because of the Diabetic Ketoacidosis, coma and lung infection. During the period of therapy, almost no side effects but 2 patients with diabetes had increase in blood suger. Conclusion: The combination of Xiaoaiping, somatostatin analog-Octretide Acetate and Prednisone,may be a effetive method to cure senile lymphoma,but it cannot curb the brain invasion,and no exact curative effect to brain invasion.
出处 《现代生物医学进展》 CAS 2009年第9期1733-1735,共3页 Progress in Modern Biomedicine
基金 国家民政部 中国老年学学会十一 五专项课题(项目编号:民人教科学(2007)18-2-14)
关键词 非霍奇金淋巴瘤 中药 老年 non-hodgkin lymphoma Chinese herbal drugs senium
  • 相关文献

参考文献12

  • 1米勒 霍格斯通 斯塔特 等.癌症治疗结果报告.癌症,1981,47(1):207-214.
  • 2布斯考 圣-劳伦特 卡斯特 等.在胰腺癌和大肠癌中人生长抑素受体2基因表达的缺失.癌症,1996,56(8):1823-1823.
  • 3瑞塞恩 贝尔.生长抑素受体的分子特性.神经科学,1995,67(4):777-790.
  • 4博格哈德 巴拉贝拉 马克赛可 等.在Capan-2细胞中长效生长抑素类似物对表皮生长因子活化细胞的增殖的抑制效果.巴黎生理学,2000,94(1):57-62.
  • 5奥比尼 弗洛锐欧 基恩赛吉欧 等.生长抑素通过抑制血管生长来控制卡波西肉瘤.美国实验生物学会联合会,1999,13(6):647-655.
  • 6瑞拉特 乃坡格尼.善得定治疗胰腺癌异种移植物的凋亡诱导和磷酸化.抗癌,2001,21(1):477-480.
  • 7刘文斌,李建生.生长抑素抗肿瘤机制研究进展[J].安徽医药,2005,9(1):7-9. 被引量:22
  • 8叶栋枢.乌骨藤治疗恶性肿瘤初探.中华肿瘤杂志,1987,9(2):126-126.
  • 9季宁彬,张广美.中药抗肿瘤有效成分药理应用[M].哈尔滨:黑龙江科学技术出版社,1998.
  • 10张庆民,龚惠明.抗癌中药的临床应用【M】.北京:人民卫生出版社,1998:100.

二级参考文献24

  • 1萧树东,李德华,张德中,沈谋积,朱孝庭,栗原稔.应用ACNU与Me-CCNU联合化疗治疗进展期胃癌的随机研究[J].中华肿瘤杂志,1996,18(1):30-33. 被引量:3
  • 2Florio T,Thellung S, Corsaro A ,et al. Characterization of the intra cellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro [ J ]. Clin Endocrinol(Oxf) ,2003,59 ( 1 ): 115 - 28.
  • 3Cattaneo MG, Scita G, Vicentini LM. Somatostatin inhibits PDGF stimulated Ras activation in human neuroblastoma cells [ J ]. FEBS Lett, 1999,459 ( 1 ) :64 - 8.
  • 4Pola S,Cattaneo MG, Vicentini LM. Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity [ J ]. J Biol Chem, 2003,278 (42): 40601 - 6.
  • 5Douziech N, Calvo E, Coulombe Z, et al. Inhibitory and stimulatory effects of somatostatin two human pancreatic cancer cell lines: a primary role for tyrosine phosphatase SHP-1 [J]. Endocrinology, 1999, 140(2) :765 -77.
  • 6Charland S,Boucher MJ,Houde M, et al. Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/44 mitogen-activated protein(MAP) kinase activation in normal and tumoral pancreatic acinar cells [ J ]. Endocrinology,2001,142 ( 1 ): 121 - 8.
  • 7Sharma K, Patel YC, Srikand CB, et al. Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3 [ J ]. Mole Endocrinology, 1996,10 (2): 1688 -96.
  • 8Florio T,Yao H,Carey KD, et al. Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 ( SSTR1 ) [ J ]. Mol Endocrinol, 1999,13 ( 1 ) :24 - 37.
  • 9Celinski SA, Fisher WE, Amaya F, et al. Somatostain receptor gene transfer inhibits established pancreatic cancer xenografts [ J ]. J Surg Res,2003,115(1) :41 -7.
  • 10Charland S, Boucher M J, Houde M et al. Somatostain inhibits Akt phosphorykation and cell cycle entry, but not p42/p44 mitogen-acti vated protein(MAP) kinase activation in normal and tumoral pancreatic acinar cells [ J ]. Endocrinology, 2001,142 ( 1 ): 121 - 8.

共引文献65

同被引文献30

引证文献1

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部