中药消癌平联合奥宁、强的松治疗耄耋年龄淋巴瘤的设计与临床应用的前瞻性研究报告

A Report on Prospective Study of Design and Clinical Application of Senile Lymphoma with Xiaoaiping,Octretide Acetate and Prednisone

目的:观察消癌平联合奥宁、强的松治疗耄耋年龄淋巴瘤的疗效。方法:3名年龄大于80岁的老年淋巴瘤患者,不能接受化疗,血生化、血常规检查基本正常,治疗方法:消癌平60ml+5%葡萄糖液250ml,持续静脉滴注16天,奥宁0.8mg+生理盐水100ml,Civ(连续静脉泵入),(2ml/小时/48小时)×8次(16天);强的松片40mg,连续口服14天。按实体瘤近期疗效标准评价疗效。结果:总疗效CR1例,PR2例。3例患者中有2例目前仍存活,生活能自理。一例骨浸润伴骨破坏者,治疗后骨缺损稳定2个月以上无变化,但在CR后2个月进行巩固治疗期间发现脑浸润;一例患者在首次治疗期间发现脑浸润,经治疗后病灶稳定、无变化;另外一例患者在5次治疗出院后,因糖尿病诱发酮症酸中毒、昏迷、肺部感染,死亡。治疗期间除2例伴发糖尿病患者血糖增加外,几乎未见任何副作用。结论:消癌平、生长抑素类似物--奥宁、强的松联合应用,可能是治疗老年淋巴瘤的有效的治疗方法,但该方法不能扼制脑浸润的发生,对脑浸润也无确切的治疗效果。

Objective： To observe the curative effect of Xiaoaiping, Octretide Acetate and Prednisone on senile lymphoma. Meth- otis： 3 patients with lymphoma ,aged more than 80 years and not accepting chemotherapy and with fundamental normal blood routine and biochemistry tests,were given Xiaoaiping 60m1＋5% Glucose injection 250ml, ivgtt,qd for 16 days; Octretide Acetate 0.8mg＋ physiological saline 100ml, Civ（continue intervenous） （2ml/h/48h）× 8（16 days）; and Prednisone tablets 40mg（ per os for 14 days）.Evaluate the curative effect according to the evaluation criteria in solid tumor. Results： 1 patient in CR,2 of PR .2 in these 3 patients still survive at present and could take care of themselves, one patient with bone infiltration and destruction ;after treatment there was no changes in bone destrction in more than 2 months, But in the stage 2 months later than CR ,we discovered brain invasion; 1 patient with brain invasion in the first therapy stage, and no changes in the focus after treatment; another patient died after 5 treatments because of the Diabetic Ketoacidosis, coma and lung infection. During the period of therapy, almost no side effects but 2 patients with diabetes had increase in blood suger. Conclusion： The combination of Xiaoaiping, somatostatin analog-Octretide Acetate and Prednisone,may be a effetive method to cure senile lymphoma,but it cannot curb the brain invasion,and no exact curative effect to brain invasion.