T-淋巴细胞成熟相关性蛋白基因在正常喉黏膜和喉良性病变及喉癌中的表达和意义

Expression pattern of MAL in normal epithelial cells,benign tumor,and squamous cell carcinoma of larynx

目的:研究MAL在正常喉黏膜组织、声带息肉、喉不典型增生组织及喉癌中表达进而分析其不同分布的意义。方法:运用免疫组织化学的方法检测MAL在正常喉黏膜组织、声带息肉、喉不典型增生组织及喉癌中分布情况。结果:MAL在正常喉黏膜组织中存在表达。比较正常喉黏膜组织和声带息肉组织,MAL表达情况无明显差异。比较正常喉黏膜组织、喉不典型增生及喉癌,MAL在喉不典型增生和喉癌中均表达下调,MAL在喉鳞状细胞癌中表达较喉不典型增生中明显下调。结论:MAL存在正常喉黏膜组织中,在癌变早期时因细胞功能变化而发生表达改变。可作为喉鳞状细胞癌早期诊断的指标之一。

Objective：To compare the expression pattern of the MAL protein in normal and laryngeal carcinoma to derive possible implications of MAL in carcinoma development of larynx. Method：Use the immunohistochemical technique to analyze the distribution of MAL in normal laryngeal epithelial cells, polyp of vocal cords, laryngeal atypical hyperplasia and laryngeal squamous cell carcinoma. Result： MAL-like immunohistochemical reactions are strongly expressed in normal laryngeal epithelial cells and its expression is no significantly different in epithelial cells of the polyp of vocal cords. Comparatively, MAL expression is significantly down regulated in laryngeal atypical hyperplasia and laryngeal squamous cell carcinomas（P〈0.05）. Conclusion： MAL is normally expressed in laryngeal epithelial cells and its expression changes at early stages of carcinoma development. MAL, therefore, is a potential marker for early diagnosis of laryngeal squamous cell carcinoma.