2,4-二溴苯酚的合成实验

Trial on the Synthesis of 2,4-dibromophenol

研究了以苯酚为原料，在乙醇一水介质中，进行溴化反应生成2，4-二溴苯酚的优化工艺条件。合成最佳反应条件为：苯酚、溴素与双氧水的物质的量比为1：0．98：0．98，演化反应温度为0—5℃；反应时间为2h；洗涤温度为40—50℃。优化条件下，收率可达96％，产品经质谱验证及气相色谱分析，百分含量为98．3％。

The optimization of process conditions was sent out to synthesize 2,4 - dibromohenol with phenol as raw materials and in the ethanol - water media. The optimal reactive conditions were obtained as follows, the molar ration of phenol , bromine and hydrogen peroxide was 1 ： 0.98 ： 0.98, the reaction temperature of the bromination was 0 - 5℃, the reaction time,the washing temperature was 40 -50℃. The yield on charge was 96% under this condition. The product was analyzed and confirmed by MS spectrum and GC ,the mass concentration was 98.3%.