长期小剂量利尿剂治疗慢性收缩性心力衰竭的疗效和安全性观察

Observation on the Long-term Therpeutic Effect and Safety of Low Dose Diuretics in Chronic Systolic Heart Failure

目的观察长期口服小剂量利尿剂治疗慢性收缩性心力衰竭的疗效和安全性。方法将61例慢性收缩性心力衰竭患者随机分为A(n=31)、B(n=30)2组。在给予ACEI、β受体拮抗剂等治疗的同时,A组给予氢氯噻嗪;B组给予呋塞米。于服药开始及服药后3、6、12个月分别监测左室射血分数(LVEF)、血尿酸、空腹血糖、血肌酐及血清钾等指标,并进行6 min步行试验。结果2组治疗6个月后,LVEF6、min步行试验结果与治疗前相比,均显著增加(P<0.05);2组治疗前后血尿酸、空腹血糖、血肌酐及血清钾等均无显著改变(P>0.05)。结论长期口服小剂量利尿剂治疗慢性收缩性心力衰竭的疗效可靠、安全。

Objective To observe the long-term clinical therapeutic effect and safety of low dose diuretics in chronic systolic heart failure. Methods Sixty-one randomized enrolled patients with stabile conditions were randomized into two groups,group A （n=31） and group B （n=30）. Both groups were given ACEI and Q-block, at the same time the patients in group A were given hydrochlorothiazide and the patients in group B were given furosemide. The Left ventricular ejection fraction（LVEF ）, serum uric acid, blood glucose, serum creatinine, serum potassium and 6 minutes walk test of the patients were measured on the 1st day, in 3 months, in 6 months and in 12 months. Results The LVEF and 6 minutes walk test of two groups were significantly improved after the treatment of 6 months（P〈0.05）. The serum uric acid,blood glucose, serum ereatinine potassium and plasma of two groups had not significant difference between on the 1st day and after the treatment of 12 months（P〉0. 05）. Conclusion The long-term clinical therpeutic effect of low dose diuretics in the treatment of chronic systolic heart failure is safe and effective.