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ApoE4对大鼠在体海马长时程增强的影响

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摘要 目的探讨载脂蛋白E(apoE)对大鼠在体海马长时程增强(LTP)诱导及维持的影响。方法①电生理手段记录大鼠在体海马CA1区场兴奋性突触后电位(fEPSPs)变化;②通过侧脑室注射给药观察重组人apoE4及apoE3对LTP形成的影响。结果①高频刺激(HFS)成功诱导海马CA1区LTP,不同apoE异构体(apoE4,apoE3)对大鼠在体海马LTP具有不同的作用;②ApoE4对大鼠海马LTP的抑制作用具有时间依赖性。结论ApoE4预处理时间依赖性压抑了海马LTP的诱导和维持;apoE3对海马LTP的诱导和维持无影响。
作者 王瑞锋 李新毅 刘鑫爱 李雯
机构地区 山西医科大学 山西医科大学第一临床医学院
出处 《中西医结合心脑血管病杂志》 2009年第5期574-575,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词 载脂蛋白E 长时程增强 海马 大鼠
分类号 R749.1 [医药卫生—神经病学与精神病学] R285.5 [医药卫生—中药学]
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参考文献19

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二级参考文献17

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中西医结合心脑血管病杂志
2009年 第5期

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