第三代头孢菌素类抗生素临床安全用药分析

Analysis of Clinical Safety Application of The Third Generation Cefazolin

目的调查分析2005年1月-2008年12月共596例头孢菌素类抗生素临床应用状况,分析不良反应发生的原因,指导临床安全用药。方法采用回顾性分析方法对全年应用头孢菌素类抗生素的病例进行总结。结果头孢菌素类抗生素的不良反应与患者是否属于过敏体质、是否皮试、用药剂量、药物配伍、是否联合用药等诸多因素有关。结论要根据患者药代谢动力学特点合理用药,以确保头孢菌素类抗生素的安全用药。

Objective To investigate and analyze the clinical application of cefazolin antbiotics of 596 cases in our hospital from Jan,2005 to Dec 2008 and analyze the reasons of side effect occuring,to guide the safety application. Methods To conduct the retrospective analysis on the data of cases using cefazolin in the whole year. Results The side effect occuring of the cefazolin is related to the following factors such as allergy physique, skin test, dosage, etc. Conclusion Doctors should reasonablly use the medicine according to the characteristic of pharmacokinetics to ensure the safe use of the cefazolin anti biotics.