我院2007—2008年多发性消化性溃疡发病及诊治情况分析

An analysis of Morbidity, Diagnosis and Treatment of Multiple Peptic Ulcer

目的探讨多发性消化性溃疡的发病及诊治情况。方法回顾性分析本院2007-2008消化内科胃镜检查等临床资料。结果2007、2008年消化性溃疡检出率分别为23．57％；25．19％，差异无统计学意义（P〉0．05）。多发性溃疡各占6．41％；6．33％，差异无统计学意义（P〉0．05）。2007、2008年多发性消化性溃疡损害因素HP感染率分别为80．77％；82．76％，药物因素各占42．31％；37．93％，血清胃泌素平均值分别（139±21．3），（141±20．9），差异均无统计学意义（P〉0．05）。并发症出现率分别为30．77％；37．93％，差异无统计学意义（P〉0．05）。两种不同治疗方法患者症状缓解、溃疡愈合不良反应比较无统计学差异（P〉0．05）。HP根除率分别71．43％；95．24％，差异有统计学意义（P〈0．05）。结论多发性消化性溃疡在消化性溃疡中的发病率相对稳定，HP、NSAID与胃泌素仍是最重要的致病因素，以埃索美拉唑＋左旋氧氟沙星为中心的三联疗法明显优于传统的治疗方法。

Objective To explore the Morbidity, Diagnosis and Treatment of Multiple Peptic Ulcer. Methods We retrospectively analyzed the gastroscopy and other clinical data of department of Digestion Medicicn of our hospital sine 2007 - 2008. Results 2007,2008 peptic ulcer in detection rates were 23.57% ; 25.19% ,the difference was not significant（P 〉0. 05）. Multiple ulcers for Each 6. 41% ; 6. 33% ,there was no significant difference （ P 〉 0.05 ）. 2007,2008 damage factor in peptic ulcer multiple HP infection rates were 80.77% ; 82. 76% ,Drug factors42. 31% ; 37.93%, ,the average serum gastrin 139 ±21.3 ; 141±20. 9 ,statistical significance（ P 〉 0. 05 ）. Complication rate of 30.77% ; 37. 93%, the difference was not significant （ P 〉0. 05 ）. Two different treatment methods in patients with symptoms, ulcer healing compared adverse reactions was no significant difference（ P 〉 0.05 ）. HP eradication rates were 71.43% ; 95.24% , the difference was statistically significant （ P 〈 0.05 ）. Conclusion Multiple peptic ulcer in the incidence of peptic ulcer is relatively stable, HP, NSAID and Gastrin is still the most important pathogenic factors, esomeprazole ＋ Levofloxacin triplecentric therapy was superior to the traditional method of treatment.