单纯性肥胖患者血清抵抗素和脂联素水平的研究

Levels of serum resistin and adiponectin in simple obesity patients

目的探讨单纯性肥胖患者血清抵抗素和脂联素水平的变化及意义。方法分别测定单纯性肥胖组(40例)和正常对照组(42例)的体质量指数(BMI)、腰围(WC)、腰臀比(WHR)、抵抗素、脂联素、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平。结果单纯性肥胖组的抵抗素和脂联素水平与对照组相比差异有统计学意义(均P<0.01),抵抗素分别为(25.79±6.14)μg/L vs(15.76±4.39)μg/L(P<0.01);脂联素分别为(2.58±1.03)mg/L vs(7.29±2.14)mg/L(P<0.01)。抵抗素水平与BMI、WC、WHR、FINS和HOMA-IR、WHR、LDL-C呈正相关(r=0.523,P<0.01;r=0.608,P<0.01;r=0.350,P<0.05;r=0.501,P<0.01;r=0.317,P<0.05);脂联素则仅与HDL-C呈正相关(r=0.331,P<0.05),与BMI、WC、WHR、FBG、FINS、HOMA-IR、TG、LDL-C呈负相关(r=-0.649,P<0.01;r=-0.744,P<0.01;r=-0.712,P<0.01;r=-0.357,P<0.05;r=-0.631,P<0.01;r=-0.685,P<0.01;r=-0.384,P<0.05;r=-0.364,P<0.05);抵抗素与脂联素两者呈负相关(r=-0.517,P<0.01)。抵抗素和脂联素是BMI和WC的预测因素。结论抵抗素升高、脂联素降低易导致单纯性肥胖和胰岛素抵抗。抵抗素、脂联素水平可能是肥胖发生的预测指标。

Objective To explore the levels of serum resistin and adiponectin in simple obesity patients and also to investigate their roles in this disease. Methods The serum resistin, adiponectin, anthropometric and biochemical measurements of body mass index （BMI）, waist circumference （WC）, waist hip ratio （WHR）, fasting blood glucose （FBG）, fasting insulin （FINS）, total cholesterol （TC）, triglyeeride （TG）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol（LDL-C） were performed in 40 simple obesity subjects and 42 normal subjects. Results Resistin level in obesity group was significantly higher than that in normal group （25.79 ± 6.14） μg/L vs （15. 765±4.39） μg/L, but level of adiponeetin was lower （2. 585= 1.03） mg/L vs （7.29 ± 2.14） mg/L （both P 〈 0.01）. Resistin level was positively correlated with BMI, WC, WHR, FINS, HOMA-IR （ r = 0. 523, P 〈 0.01; r = 0. 608, P 〈0.01; r =0. 350, P 〈0.05; r =0. 501, P 〈0.01; r =0. 317, P 〈0.05）,but adiponectin level was in positive correlation with HDL-C （ r = 0. 331, P 〈 0.05）. Furthermore, adiponectin was negatively associated with BMI,WC,WHR,FBG,FINS, HOMA-IR,TG,LDL-C （ r =-0. 649, P 〈0.01; r =-0. 744, P 〈0. 01; r =-0. 712, P〈0.01; r =-0.357, P 〈0.05; r =-0.631, P〈 0.01; r =-0.685, P 〈0.01; r =-0.384, P 〈0.05; r = - 0. 364, P 〈0.05）. Resistin level had negative correlation with adiponection level（ r = - 0.517, P 〈0.01）. Resistin and adiponectin can predict the BMI and WC well. Conclusion The serum resistin and adiponectin take part in the development of simple obesity and insulin resistance. Resistin and adiponectin level may be predictive indexes for obesity.