胞磷胆碱治疗新生儿缺氧缺血性脑病

Citicoline in treating newborn infants with hypoxic_ischemic encephalopathy

目的：观察胞磷胆碱加对症治疗对中、重度新生儿缺氧缺血性脑病的疗效。方法：新生儿缺氧缺血性脑病８０例（男性４４例，女性３６例；年龄为生后２４ｈ内）给予胞磷胆碱０．１２５ｇ，ｉｖ，ｄｒｉｐｑｄ，共用７～１０ｄ。同时应用吸氧、碳酸氢钠、补液、止惊、能量合剂等对症治疗，对照组为同样病人６０例（男性３８例，女性２２例；年龄同治疗组）只应用上述对症治疗。结果：治疗组总有效率９５％；对照组有总有效率６８％，Ｐ＜０．０１。结论：胞磷胆碱加对症治疗对新生儿缺氧缺血性脑病的效果较单纯对症治疗为优。

AIM: To observe the therapeutic effect of citicoline plus symptomatic treatment in treating newborn infants with moderate and severe hypoxic_ischemic encephalopathy (HIE). METHODS: The 80 patients (M 44, F 36, age within 24 h after birth) received citicoline 0.125 g, iv, drip, qd, a course of 7_10 d, plus symptomatic treatment, including oxygen inhalation, 5% sodium bicarbonate, fluid therapy, anticonvulsant, energetic mixture. The other 60 patients (M 38, F 22, age <24 h ) as control received symptomatic treatment only. RESULTS: The total effective rates were 95% in therapy group and 68% in the control group (P<0.01). CONCLUSION: citicoline is effective for HIE.