丁螺环酮与地西泮治疗焦虑症双盲比较

Buspirone vs diazepam in treating anxiety disorders in a double_blind study

目的：比较丁螺环酮与地西泮治疗焦虑症的疗效及不良反应。方法：采用随机双盲对照研究的方法，分为丁螺环酮组２３例（男性１１例，女性１２例；年龄３８±ｓ１３ａ），予丁螺环酮１５ｍｇ，ｐｏ，ｔｉｄ；４ｗｋ为一个疗程。地西泮组２２例（男性９例，女性１３例；年龄４１±１３ａ），予地西泮７．５ｍｇ，ｐｏ，ｔｉｄ；４ｗｋ为一个疗程。结果：丁螺环酮组有效率为８７％，地西泮组９１％，２组比较Ｒｉｄｉｔ分析Ｐ＞０．０５。药物不良反应发生率地西泮组高于丁螺环酮组，但反应轻微不影响治疗。结论：丁螺环酮与地西泮疗效相同，不良反应少。

AIM: To compare the effects and adverse reactions of buspirone and diazepam in treating anxiety disorders. METHODS: Forty_five anxious patients were divided randomly into 2 groups: 23 patients (M 11, F 12, age 38±s 13 a) were treated with buspirone, 15 mg, po, tid for 4 wk; 22 patients (M 9, F 13, age 41±11 a) were treated with diazepam, 7.5 mg, po, tid for 4 wk. RESULTS: The total clinical effective rates were 87% for buspirone, and 90% for diazepam (P>0.05). The adverse reactions in diazepam group was higher than in buspirone group. But this did not hinder the treatment because the adverse reactions were mild. CONCLUSION: Buspirone showed the same effects but less adverse reactions than diazepam.