豚鼠畸变产物耳声发射正常值测试及其相互关系

Determination of normal values and analysis of their relation for distortion product otoacoustic emission in guinea pigs

为探讨豚鼠1，2，4，6kHz的畸变产物耳声发射（DPOAE）正常值，对12只（15耳）豚鼠DPOAE进行了较系统的测试，并就其间的相互关系进行了分析。各频率的测出率均为100％；2kHz以上的幅值均在25dBSPL以上，1kHz的幅值低于其它频率；2kHz以上的反应阈值低于1kHz；潜伏期随频率的增加有缩短的趋势；I／O函数曲线表明各频率的DPOAE幅值随初始音的强度降低而减小，两者间存在着极显著的相关性。结果表明豚鼠的DPOAE测出率高，幅值大，各项指标反应稳定。提示豚鼠是一种研究DPOAE较为适宜的实验动物。

In the present paper,we measured systematically the normal values of 1, 2, 4, 6 kHz distortion product otoacoustic emission (DPOAE) in guinea pigs and analyzed the relation of these values. The incidence of DPOAE in all frequencies were 100%. The amplitudes of DPOAE above 2 kHz were larger than 25 dB SPL,but the amplitude of 1 kHz was lower than one of above 2 kHz.The threshold of above 2 kHz were lower than one of 1 kHz. A trend was found that latencies of all frequencies decreases accompanied with the f_2 frequencies increasing. I/O function curves demonstrated that there was a significant relation between the amplitudes of DPOAE and the levels of primary stimuli in the statistics,that is,lower levels of primary stimuli and smaller amplitudes of DPOAE. Our results indicated that a guinea pig,whose DPOAE possessed the properties of high incidence, large amplitude and stable responsibility, was an appropriate experimental animal for studying DPOAE,In addition,this paper recommended briefly the experience about the measuring techniques for DPOAE in guinea pigs.