慢性特发性荨麻疹患者口服抗组胺药治疗依从性分析

Analysis of the compliance of oral antiallergics for treatment of chronic idiopathetic urticaria

目的:了解慢性特发性荨麻疹患者口服抗组胺药治疗的依从性及影响因素。方法:将112例患者随机分为A、B两组,A组口服左西替利嗪片、酮替芬片和西咪替丁片;B组口服地氯雷他定片,两组患者均服药8周。采用自编问卷对每例患者进行调查。结果:平均服药依从率为68.75%。依从者治疗有效率为68.83%,不依从者有效率为31.43%,依从率和年龄、病程、治疗方案有显著性相关(P<0.05),与性别、文化程度无显著性关系(P>0.05)。不依从原因主要为患者对疾病危害性缺乏了解或担心副作用或认为已治愈自行停药。结论:慢性特发性荨麻疹患者口服抗组胺药治疗的依从性较低且其对疗效影响显著。年龄、病程和治疗方案对依从性有影响。

Objective： To understand the compliance and influence factor on chronic idiopathetie urticaria with oral antiallergies. Methods： 112 patients were randomly divided into A group and B group. Patients were treated with levocetirizine, ketotifen and cimitidine （A group） and desloratadine （B group）, during the course of treatment for 8 weeks. Self-administered questionnaire was applied in the survey on every patient. Results ：The average rate of compliance was 68.75%, the effect rate for those compliance with doctors＇ order was 68.83%, while it was only 31.43% for those noncompliant patients. It was found that the compliant rates were significantly correlated to ageing, the therapy scheme and course （P〈0.05）, while no significant correlations were seen between male and female, culture degree （P〉0.05）. Among the noncompl.iant ones, patients mainly did not understand hazardousness of chronic idiopathetic urticaria or patients were worried about the side effects of medicine or thought that they had already been cured. Conclusion： Our results showed that the compliance was low which exerted a significant influence on the curative effect of chronic idiopathetie urticaria patients. Factors as ageing, the therapy scheme and course has an influence on the compliant rate.