通络祛湿除痹汤治疗类风湿性关节炎临床研究

Clinical observation on Tongluoqushichubi Decoction in treating 60 cases of rheumatoid arthritis

目的:观察通络祛湿除痹汤治疗类风湿性关节炎的临床疗效。方法:对照组用西药甲氨蝶呤片治疗;治疗组除服用对照组西药外(服用方法完全与对照组相同),另给予中药通络祛湿除痹汤治疗,并进行回顾分析总结。结果:①治疗组总有效率为93.33%,对照组为81.48%,两组近期疗效比较有显著性意义(P<0.05);②两组关节炎症指数治疗前后差值的比较:疼痛指数差值变化有显著差异(P<0.05),肿胀指数及功能障碍指数的差值变化则无统计学意义(P>0.05);③治疗组RF转阴率为57.14%,对照组RF转阴率为27.27%,经比较有显著意义(P<0.05),两组ESR治疗前后比较均有显著差异(P<0.05),而治疗前后差值比较则无统计学意义(P>0.05)。结论:通络祛湿除痹汤治疗组比单纯西药治疗对照组缓解患者的关节疼痛症状更迅速,具有较好的短期疗效。

Objective ： To observe the therapeutic effect of Tongluoqushichubi Decoction in treating rheumatoid arthritis （RA）. Methods： 27 patients in the control group were given western medicine Methotrexate tablets. 60 patients in theraputic group, in addition to be based on the treatment of western medicine, were treated with Tongluoqushichubi Decoction. Results： （1）The total effective rate in theraputic group was 93.33%, as compared with 81.48% in control group （P〈0. 05） in near future effect. （2）Comparison of the difference of before and after treatment evaluation in the patients＇ joint inflammation index of the two groups： the difference of evaluation in the patients＇ joint pain index was significant（P〈0. 05）. The change of the difference of evaluation in the patients＇swelling and disability index had not significance of statistics （P〉0. 05）. ORF disappeared in theraputic group was 57.14%, RF disappeared in control group was 27.27%, compared with two groups, it was significant（P〈0. 05）, compared with two groups of before and after treatment in ESR was significant（P〈0. 05）. The ESR difference of before and after treatment evaluation had not significance of statistics （P 〉 0. 05）. Conclusion： The results indicated the theraputic group Tongluoqushichubi Decoction compared with the control group （western medicine only） in releasing patients＇joint pain symptom, the former is more quick than the latter. Tongluoqushichubi Decoction has better short-term effect.