血清胃蛋白酶原含量检测在胃病诊断中的应用

Clinical Application of Serum Pepsinogen Levels in Patients with Intestines and Stomach Disease

目的；探讨不同胃肠疾病与血清胃蛋白酶原（PG）的关系。方法：用放射免疫分析法检测179例各型胃肠病患者血清胃蛋白酶原含量。结果：慢性浅表性胃炎患者与对照组比较，血清PGⅠ水平差异无显著性（P〉0．05），血清PGⅡ显著性上升（P〈0．05）；轻度慢性萎缩性胃炎和重度慢性萎缩性胃炎患者与对照组比较，血清PGⅠ水平显著下降（P〈0．05），PGⅡ差异无显著性（P〉0.05），PGⅠ／PGⅡ比值下降；十二指肠球部溃疡和胃溃疡患者与对照组相比，血清PGⅠ和PGⅡ均显著性增高（P〈0．05）；胃癌患者与对照组相比，PGⅠ显著性下降（P〈0．01），PGⅡ差异无显著性（P〉0．05），PGⅠ／PGⅡ比值降低。结论：血清PGⅠ水平及PGⅠ／PGⅡ比值的改变，可以作为临床诊断不同胃肠疾病和胃癌的参考指标。

Objective： To investigate the relation between different intestines and stomach diseases and pepsinogen （PG）. Methods： Measuring the serum PG levels of 179 various patient of intestines and stomach disease by radioimmunoassay. Making analysis on the values of the serum PG. Results： Compared with control group, the PGⅠ value of the Chronic simple form gastritis patients is not significantly different （P〉0.05）, PGⅡ increases prominently; chronic shrinking gastritis and severe chronic shrinking gastritis patient compared with control group slightly, PGⅠ significantly declines （P 〈0. 05）, PGⅡ difference has no significance （P〉 0. 05）, and PGⅠ/PGⅡ drops to some extent; duodenum ball ulcer and gastric ulcer patient compared with control group, serum PGⅠ and PGⅡ significantly rise （P〈0.01） ; compared with control group the gastric carcinoma patient, PGⅠ significantly declines （P 〈0.05）, PGⅡ difference has no significance （P〉 0.05）, and PGⅠ/PGⅡ drops to some extent. Conclusion： Serum PGⅠ and PGⅠ/PGⅡ change of level can be an index of diagnosing different intestines and stomach diseases.