摘要
目的：减少术中胃液分泌量或／和提高其ＰＨ对于降低全麻误吸的危险性具有重要的价值，方法：本研究选择４５例神经外科病人，采用随机、双盲、空白对照研究方法，对比观察了术前３０ｍｉｎ静注雷尼替丁５０ｍｇ或西咪替丁２００ｍｇ对术中胃液分泌量和酸度的影响。结果：表明雷尼替丁５０ｍｇ可显著降低胃液分泌量，并升高胃液的ＰＨ值；而西咪替丁则无明显的作用。结论：术前应用雷尼替丁可抑制胃液的分泌，并降低其酸度。
It is very important to decrease the gastric volume and acidity and reduce the risk for acid aspiration during general anesthesia.In this randomizded,doubel-blinded and placebo-controlled study,the effect of ranitidine,50mg i.v.and cimetidine,200mg i.v,as a premedication on the secretion and acid of gastric fluid in 45 neurosurgical patients.The results showed that ranitidine,not cimetidine,decreased the volume and increased the pH of gastric content significantly during propofol-isoflurane general anesthesia.It was concluded that ranitidine,i.v.30min prior to anesthesia,is effective for decreasing the gastric volume and acidity.
出处
《河北医学》
CAS
1998年第1期23-25,共3页
Hebei Medicine
