红花对下肢深静脉介入溶栓血液流变学的影响

Effect of honghua injection on hemorheological indexes in lower extremity deep venous thrombosis through catheterization

目的研究红花注射液在介入治疗下肢深静脉血栓术后血液流变学指标变化及临床价值。方法经彩超及静脉造影证实有下肢深静脉栓塞患者30例,随机分为对照组和研究组,各15例。行顺行插管介入溶栓术治疗,对照组仅以尿激酶为溶栓剂,研究组在注入尿激酶后加注红花注射液,术后三天复查造影观察疗效,出院后随访,观察介入术后各项血液流变性指标的改变、治疗的有效率、治愈率、复发率及并发症。结果经红花注射液治疗后,两组患者各项血液流变性指标均有降低,研究组血液流变性指标较治疗前下降明显;全部病例临床症状明显减轻,仅遗留轻度患肢肿胀。结论红花注射液具有降低血粘度的作用,能保护血管内皮细胞、降凝、溶栓、扩张血管以及与尿激酶的协同作用,从而提高治疗效果,减少术后复发,在治疗下肢深静脉血栓中有一定的临床价值。

Objective To observe the effect of honghua injection on hemorheological indexes and its clinical effectiveness in interventional therapy of lower extremity deep venous thrombosis（LEDVT）. Method 30 lower extremity deep venous thrombosis patients diagnosed with color Doppler imaging and phlebography were randomly divided into control group and research group, 15 respectively. Antegrade catheterization was carried out in all the cases. The patients in research group were injected honghua injection after Urokinase, while the control group were injected Urokinase only. Phlebography was rechecked three days after interventional therapy to observe the effect. Both groups were followed up on hemorheological indexes, effective rate,cure rate relapse rate and complication. Results Hemorheological indexes of both groups were decreased, especially significantly in research group. Clinical symptoms were obviously lessened in all the cases,remaining slight swelling on affected limb. Conclusions Honghua injection could lower blood viscosity, protect vascular endothelial cell, expand blood vessel, and there was an obvious therapeutic efficacy to decrease relapse rate in coordination with Urokinase. It play an important clinical role in the treatment of LEDVT.