小剂量美托洛尔治疗慢性心力衰竭66例临床观察

目的观察联合β受体阻滞剂小剂量美托洛尔治疗慢性心力衰竭(CHF)的临床疗效及安全性。方法选择慢性充血性心力衰竭患者130例,治疗组66例在常规治疗的基础上加用小剂量美托洛尔治疗。观察治疗前后静息心率(HR)、收缩压(SBP)、舒张压(DBP)、心功能级别、左室舒张末内径(LVEDD)和左室射血分数(LVEF)。结果两组患者的各项指标在治疗后均较治疗前有明显改善,但治疗组较对照组改善更为显著(P<0.05)。结论在常规抗心衰治疗基础上加用小剂量美托洛尔可明显改善患者心功能,是一种安全、有效的治疗方法。

Objective To study the clinical effects and safety ofmetoprolol for chronic heart failure（CHF）.Methods 130 patients with CHF（cardiac function NYILA Ⅱ- Ⅳ class）were divided randomly into two groups： treatment group（66cases） was added with metoprolol at a small dose. The observable factors were heart rate, systolic blood pressure（SBP）, diastolic blood pressure（DBP）, heart functional class, left ventricular end diastolic diameter（LVEDD） and left ventricular ejection fraction（LVEF） and so on. Results After treatment, the observable factors in both groups were improved magnificently. The improvement in Ireatment group was markedly superior to the control group（P〈0.05）. Conclusion Metoprolol at a small dose is an effective medicine and safety for patients with CHF.