单精子卵胞浆内注射治疗梗阻性无精子症的临床疗效分析

目的探讨单精子卵胞浆内注射(ICSI)治疗梗阻性无精子症的临床疗效。方法选择2006年10月～2008年7月因男性不孕症夫妇行ICSI治疗的患者638例分成两组,ICSI组和TESA+ICSI组,ICSI组为自行排精后精液内可以找到正常形态活精子的少精症患者行ICSI治疗584例,TESA+ICSI组为梗阻性无精子症患者经睾丸穿刺找到睾丸内形态正常活精子行ICSI治疗共54例,两组女方均给予超促排卵用药获取卵母细胞。结果虽然TESA+ICSI组受精率较ICSI组稍低(P<0.05),但两组卵裂率、优质胚胎率、种植率和临床妊娠率均没有统计学差异(P>0.05)。结论TESA+ICSI是治疗梗阻性无精症的有效方法。

Objective To investigate the clinical efficiency of intracytopalmic sperm injection （ICSI） with testicular sperm aspiration in the treatment of obstructive azoospermia. Methods Male infertility couples from October 2006 to July 2008 were chosen and divided into ICSI group and TESA＋ICSI group. ICSI group were 584 oligozoospermia cases with alive normal sperm in spermatic fluid. TESA＋ICSI group were 54 obstructive azoospermia cases with alive normal sperm in testicle. Two groups were treated with ICSI after wives obtained oocytes by ovarian stimulation. Results in spite of the fertilization rate was lower in TESA＋ICSI group compared with ICSI group, the cleavage rate, the high-grade embryo rate, the implantation rate and the pregnant rate in TESA＋ICSI group were similar to those in ICSI group. It has no significant difference between two groups （P〉0.05）. Conclusion TESA＋ICSI are efficient in treatment of azoospermia.