琥珀酸氢化可的松联合低剂量丙种球蛋白治疗儿童过敏性紫癜疗效观察

目的观察琥珀酸氢化可的松联合低剂量丙种球蛋白治疗儿童过敏性紫癜的疗效,为临床治疗提供依据。方法选取过敏性紫癜患儿70例,分为两组,对照组给予常规治疗;治疗组在此基础上给予琥珀酸氢化可的松、低剂量丙种球蛋白联合治疗,观察其药物疗效。结果治疗组总有效率明显高于对照组(P<0.05);治疗组尿常规检查恢复时间与对照组无显著性差异(P>0.05),皮疹消退、关节肿痛与消化道症状缓解时间明显缩短(P<0.01)。结论琥珀酸氢化可的松联合低剂量丙种球蛋白治疗儿童过敏性紫癜疗效良好,能明显缓解过敏性紫癜的临床症状,减少其复发率。

Objective To investigate the effect of hydrocortisone succinate combined with low-dose gamma globulin in treatment of childhood Henoeh-Schonleiri Purpura.Methods 70 patients of childhood Henoch-Schonlein Purpura were divided into two groups, treatment group and control group. The control group were treated with general methods. The treatment group was treated with Hydrocortisone succinate and low-dose gamma globulin outside general methods. The therapeutic effect of two groups were observed. Results The effective rate of the treatment group were mueh better than that of the control group（P〈0.05）;the recovery time of urine routine test of the treatment group was no significant difference compared with control group（P〉0.05）; remission time that the erythema disappeared, articular pain and digestive tract symptom shortened （P〈0.01）.Conelusion It is a good treatment to united application of hydrocortisone succinate and low-dose gamma globulin of childhood Henoch-Schonlein purpura, which can significantly improve the patients＇ clinical symptoms and reduce the relapse rate.