微量营养素对艾滋病病毒感染者体内免疫细胞及微量元素水平影响的研究

Impact of micronutrients on immunocyte and microelements status among people living with HIV

目的研究微量营养素对HIV感染者体内免疫细胞及微量元素水平的影响。方法选择25～49岁的HIV感染者，试验组服用复合微量营养素片，对照组服用安慰剂。试验开始及结束时分别进行体格测量、免疫细胞及微量元素水平的测定。结果试验前试验组与对照组的身高、体重和微量营养素摄入、免疫细胞及微量元素水平差异均无统计学意义（P〉0．05）。6个月后，试验组免疫细胞（CD4^＋、CD8^＋、CD3^＋T淋巴细胞）分别为（2078±108）个／mm^3、（582±75）个／mm^3、（1287±97）个／mm^3，高于对照组的（1436±105）个／mm^3、（472±61）个／mm^3、（998±84）个／mm^3，差异有统计学意义（P〈0．05）。试验组血清锌、钙、镁、铁分别为（144．89±9．78）μmol／L、（1．89±0．19）μmol／L、（1．68±0．12）μmol／L、（152．61±8．94）μmol／L，高于对照组（102．67±5．45）μmol／L、（1．13±0．07）μmol／L、（0．85±0．05）μmol／L、（89．24±3．91）μmol／L，差异有统计学意义（P〈0．05）。结论补充微量营养素能提高HIV感染者体内锌、钙、镁、铁的水平，并能增进免疫功能。

Objective To explore the impact of micronutrients supplement on immunocyte and microelements status in HIV positive people. Methods Volunteers aged 25-49 years old were randomly selected and distributed into two groups. Supplement and placebo were given to the two groups. At the beginning of the trial, data on physical examination, immunocyte and microelements level in serum of the two groups were collected and showed no significant difference （P〉0.05）. Results After 6 months, the amount of immunocyte （ CD4^＋, CD8^＋, CD3^＋ ） were （ 2078 ± 108 ）mm^3, （ 582± 75 ） mm^3, （ 1287 ±97 ）mm^3 in the study group while they were （1436±105） mm^3, （472 ±61）mm^3, （998± 84）mm^3 in the control group, with statistically significant difference （P〈0.05）. Amounts of serum Zn, Ca, Mg, Fe showed （144.89± 9.78） μmol/L, （1.89 ± 0.19） μmol/L, （ 1.68 ±0.12） μmol/L, （ 152.61 ± 8.94） μmol/L in the study group and they were （102.67 ± 5.45） μmol/L, （1.13 ± 0.07） μmol/L, （0.85 ± 0.05） μmol/L, （89.24 ±3.91 ） μmol/L in the control group, with statistically significant difference （P〈0.05）. Conclusion Supplementation of micronutrients could increase the levels of Zn, Ca, Mg, Fe so as to increase the immune function in people living with HIV.