摘要
目的：观察充血性心力衰竭患者血浆D-二聚体特点，以指导临床抗凝治疗。方法：采用Latex法对正常对照组30例，心功能正常组28例，心衰组58例及心衰缓解后7－10天进行血浆D-二聚体检测。结果：心衰组D-二聚体阳性率显著高于心功能正常组（P＜0.01），心功能缓解后7-10天显著下降（P＜0.05），心房纤颤组显著高于非心房纤颤组（P＜0.01），瓣膜病组显著高于非瓣膜病组（P＜0.01）。结论：充血性心力衰竭患者存在凝血及纤溶异常，心房纤颤或瓣膜病变是血栓形成的危险因素，检测血浆D-二聚体可指导抗凝治疗。
Aim: To study the feature of plasma D-dimer in patients with CHF and to guide anticoagulant therapy. Methods: The plasma D-dimer was monitored by D-dimer Latex assay in patients with CHF and remittence after 7~10days. 28 cases with normal heart function and 30 in control.Results:The positive rate of D-dimer in CHF group was significantly higher than that of normal heart function (P<0.01) and droped after 7~10 days remitting (P<0.05) The positive rate of D-dimer in the group with artrial fibrillion was higher than that of no atrial fibrillion and the pathological change of cardiac valve were higher than thoses no cardiac valve (alI P<0.01).Conclusions:Abnormality of coagulation and fibrinolysis are present in patients with CHF. Atrial fibrillion and cardiac valve disease are the danger factors of thrombosis.
