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PPAR-γ,COX-2在尖锐湿疣和鲍温样丘疹病的表达及相关性研究 被引量：1

The Expressions of PPAR-γ,COX-2 in the Lesions of Patients with Condyloma Acuminatum and Bowenoid Papulosis
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摘要 目的探讨过氧化物酶体增殖因子激活受体γ(PPAR-γ)和环氧合酶-2(COX-2)在尖锐湿疣(CA)和鲍温样丘疹病(BP)的表达,并进行相关性分析。方法CA、BP皮损和正常成年人包皮组织各17例,采用免疫组化法检测PPAR-γ、COX-2蛋白表达。结果PPAR-γ、COX-2在CA组和BP组中阳性表达均高于正常对照组(P<0.01),在CA和BP皮损中PPAR-γ的表达与COX-2呈正相关(r=0.505,P=0.038;r=0.562,P=0.019)。结论PPAR-γ、COX-2在HPV感染相关的增殖性皮肤病的发生发展中可能有重要作用。 Objective To investigate the expression of PPAR-γ, COX-2 in the skin lesion of eondyloma acuminatum and bowenoid papulosis. Methods The expression levels of PPAR-γ, COX-2 were measured by immunohistochemistry in 17 cases of condyloma acuminatum, 17 cases of bowenoid papulosis, as well as 17 cases of normal foreskin lesions. Results The immunohistochemical study showed that PPAR-γ and COX-2 weakly expressed in normal foreskin, but overexepressed in the skin lesions of both condyloma acuminatum and bowenoid papulosis（P〈0.01）. There was straight linear correlation between the expressions of PPAR-γ and COX-2 not only in condyloma acuminatum（r= 0. 505, P= 0. 038） but also in bowenoid papulosis （r= 0.562, P= 0.019）. Conclusion PPAR-γ and COX-2 may have important roles in proliferative dermatosis associated with human papilloma virus.
作者 倪均 张谊芝 薛斯亮
机构地区 四川大学华西第四医院皮肤性病科 四川大学华西医院皮肤性病科
出处 《四川大学学报（医学版）》 CAS CSCD 北大核心 2009年第3期439-441,共3页 Journal of Sichuan University(Medical Sciences)
关键词 尖锐湿疣 鲍温样丘疹病 PPAR-Γ COX-2 Condyloma aeuminatum Bowenoid papulosis PPAR-γ COX-2
分类号 R752.53 [医药卫生—皮肤病学与性病学]
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参考文献11

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共引文献91

同被引文献15

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四川大学学报（医学版）
2009年 第3期

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