腺苷负荷试验心肌灌注显像对冠心病的诊断价值

Value of adenosine ^(99m)Tc-MIBI myocardial perfusion imaging in diagnosis of coronary artery disease

目的:分析腺苷负荷试验心肌核素显像对于冠心病诊断的敏感性、特异性及其特点,评价其诊断冠心病的临床价值。方法:对68例临床疑诊冠心病患者,将其腺苷负荷试验心肌灌注显像结果与冠状动脉造影(CAG)结果进行对比分析。结果:在68例患者中,36例CAG阳性,其中腺苷心肌灌注显像检出病变33例(91.7%),未检出病变3例(8.3%);32例CAG阴性,其中腺苷心肌灌注显像异常3例(9.4%),正常29例(90.6%);腺苷心肌灌注显像对冠心病诊断的敏感性92.3%,特异性90.6%。结论:腺苷核素心肌灌注显像诊断冠心病敏感性及特异性均较高,是协助诊断冠心病的有效的无创性检查方法。

Objective：The aim of this study was to assess the value of adenosine 99mTc-MIBI myocardial perfusion SPECT for the diagnosis of coronary artery disease. Method.A total of 68 patients （ mean age [584-8] years, 38 men, 30 women） were included in this study. All patients underwent adenosine SPECT after a 6-minute infusion of adenosine （140 9g · kg^-1· min^-1） At 3 minutes of adenosine infusion, 25mCi of 99mTc-MIBI was injected, imaging acquisition was obtained 1 hour after adenosine infusion. Retrospectively analyzed the findings of coronary angiography（CAG） and myocardial perfusion imaging of all patients. Result： Among the 68 patients, 36 patients were CAG positive, among which 34（91.7%） had a abnormal adenosine myocardial perfusion imaging and two （8.3%） normal 32 out of 68 patients had normal CAG, adenosine myocardial perfusion imaging was normal in 29 （90.3 %） patients and abnormal in three （9.7%）. （sensitivity, 71%）. The sensitivity and specificity of adenosine 99mTc-MIBI myocardial perfusion imaging for detection of coronary artery disease were 92.3 % and 90.6% respectively. Conclusion Adenosine myocardial perfusion Imaging is an accurate method for detecting coronary artery disease.