摘要
Dynamin1是Dynamin家族中的一员,它在突触囊泡的内吞和循环过程中起着重要作用,但Dynamin1在应激致海马损伤过程中是否发挥作用还未见报道。为了初步探讨Dynamin1在应激致海马损伤中的作用,分别建立了海马应激损伤的动物模型和细胞模型来进行研究,研究结果表明,随着应激强度的增大,大鼠海马长时程增强(long-term potentiation,LTP)效应逐渐减弱,同时通过细胞模型FM1-43荧光染色检测到海马神经元的内吞作用也逐渐减弱,而这两个模型中Dynamin1的表达也分别相应地下降。这些结果提示:应激过程导致了Dynamin1表达水平的下降,进而造成突触囊泡的内吞过程受阻,致使海马LTP效应减弱,并最终导致海马学习记忆功能衰退。
Dynaminl is one member of Dynamin family, and it plays an important role in endocytosis and recycling of synaptic vesicles. The animal models and cell models of hippocampal injury were respectively established to study the role of Dynaminl in the hippocampal injury process. The results showed that the long-term potentiation （LTP） of hippocampus of different restraint intensity rats was gradually weakened while synaptic vesicle endocytosis was reduced in cell models, and both were accompanied by decreased expression of Dynaminl. These results indicated that the decreased expression of Dynaminl caused by stress lead to the decline of LTP effect and learning and memory weakness through inhibiting the synaptic vesicle recycling.
出处
《生物物理学报》
CAS
CSCD
北大核心
2009年第2期93-98,共6页
Acta Biophysica Sinica
