早期应用氨茶碱对窒息新生儿肾脏的保护作用

The Effects of Early Treatment of Aminophyllin on Renal Function in Neonates With Perinatal Asphyxia

目的探讨早期应用氨茶碱对窒息新生儿肾脏的保护作用。方法60例窒息新生儿随机分成试验组和对照组。在生后1h内治疗组(30例)静脉滴注小剂量氨茶碱(5mg/kg),对照组(30例)静脉滴注等量注射用水,分别收集生后24h,48h,72h左右尿液查尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活性,并每4h监测心率、呼吸、血压。结果在生后48h,72h氨茶碱治疗组尿NAG活性明显低于对照组(P<0.05),有统计学意义。两组的心率、呼吸、血压无明显差异(P>0.05)。结论早期应用氨茶碱能降低窒息新生儿尿NAG活性,改善肾脏功能,对窒息新生儿肾脏有保护作用。

Objective To study whether early treatment of aminophylline can protect renal function in neonates with perinatal asphyxia. Methods 60 neonates with perinatal asphyxia were randomly divided into 2 groups. Within the first hour after birth, the treatment group （30 cases） received intravenously a single dose of aminophylline （Smg/kg） , and the control group（30 cases） received placebo of water. Urinary Nacety - β - D - Amino - Glucosidase（NAG） activity was recorded everyday during the first 3 days of life. Heart rate, respiratory rate and blood pressure were recorded per 4h. Results Urinary NAG activity of treatment group at 48h and 72h after birth were significantly lower than that of control group （ P 〈 0.05）. There was not a statistical significance of heart rate, respiratory rate and blood pressure between two groups. Conclusion A single dose of aminophylline（Smg/kg）within the first hour of birth in neonates with perinatal asphyxia results in a significant decrease in urinary NAG activity. In conclusion, aminophylline could be used as an effective and safe therapy to renal injury in neonates with perinatal asphyxia.