摘要
目的研究热痹颗粒治疗类风湿性关节炎(RA)的作用机制。方法以雄性佐剂性关节炎大鼠(AA)作为实验模型,尪痹颗罭粜远哉找┪?随机分为6组(正常组、模型组、对照组、热痹颗粒小剂量组、中剂量组和大剂量组)进行实验研究,观察热痹颗粒对滑膜细胞的凋亡、T细胞亚群的影响,对其作用机制进行探讨。结果热痹颗粒能显著提高AA大鼠滑膜细胞的凋亡率;可显著增加CD8+细胞数量,降低CD4+细胞数量及CD4+/CD8+比值,对T细胞亚群进行双向调节。结论热痹颗粒不仅能够有效治疗RA,而且可以改善机体免疫的异常状态。
Objective To study the mechanisms of Re Bi granule on treating RA. Methods Make SD maleness rats Adjuvant - In- duced Arthritis （AA） which was derived by Freund＇ s complete adjuvant （CFA） as investigation object. Make Wang Bi granule as positive control medicine,and divide it into six groups（blank group, model group, control group, Infusion of Re Bi granule high dose group and midst dose group and low dose group）. Observe Re Bi granule＇ s influence and mechanism to synovial cell apoptosis and T cell subsets. Results Re Bi granule could distinctly heighten synovial cell apoptosis ratio of AA rats, heighten CD8^＋ cell＇ s number and reduce CD4^＋ cell＇ s number, lower CD4^＋/CD8^＋ ratio, adjust T cells for two - way. Conclusion Re Bi granule not only is an effective treatment way for rheumatoid arthritis, but also can improve the abnormal immune status.
出处
《医学研究杂志》
2009年第5期105-107,共3页
Journal of Medical Research
基金
湖北省科技厅科技攻关项目(2003AA02B02)
关键词
热痹颗粒
类风湿性关节炎
热痹
作用机制
Rc Bi granule
Rheumatoid arthritis
Beriberoid pyretic arthralgia
Mechanism
