重症肌无力患者血乙酰胆碱酯酶活性测定及其临床意义

Determination of activity of blood acetylcholin esterase in myasthenia gravis patients and its clinical significance

检测６３例重症肌无力患者和５０例正常健康人血浆乙酰胆碱酶（Ｐ－ＡｃｈＥ）活性、红细胞乙酰胆碱酯酶（Ｅ－ＡｃｈＥ）活性。结果，患者组的Ｐ－ＡｃｈＥ平均活性和Ｅ－ＡｃｈＥ平均活性皆显著高于对照组（Ｐ＜０．００１）。提示重症肌无力的发病机制除了自身免疫因素外，还有乙酰胆碱酯酶活性改变的因素。

Activity of plasma acetylcholin esterase(PAchE) and erythrocyte acetylcholin esterase(EAchE) in 63 myasthenia gravis(MG) patients and 50 healthy volunteers was determined.The results showed that the mean activity values of both PAchE and EAchE in MG group were significantly higher than those in control group(P<0.001).It is suggested that the activity changes of acetylcholin esterase in patients blood are a pathgenetic factor of MG along with autoimmunity.