放射性^(153)Sm-EDTMP对动物及人血细胞影响的研究

THE STUDIES OF INFLUENCE OF RADIOPHARMACEUTICAL153.

目的：探讨骨肿瘤治疗药物１５３Ｓｍ－ＥＤＴＭＰ对血细胞的影响。方法：用小鼠、Ｗｉｓｔａｒ大鼠和大白兔作实验。给小鼠注射的ＥＤＴＭＴ、１５３Ｓｍ－ＥＤＴＭＰ的量相当于人用量的２０００倍、２０倍，观察化学毒性和放射损伤反应。给大鼠和大白兔注射１５３Ｓｍ－ＥＤＴＭＰ的剂量相当于人用量的３０和７．５倍，于不同时间内取血测定血色素（Ｈｂ）、白细胞（ＷＢＣ）和血小板（ｐｌｔ）计数。按３７ＭＢｑ／ｋｇ注射患者，也于注射后不同时间取血检查血细胞计数的变化。结果：ＥＤＴＭＰ、１５３Ｓｍ－ＥＤＴＭＰ剂量分别大于人用量的２０００、２０倍时，未发现动物有化学毒性和放射损伤反应。给于１５３Ｓｍ－ＥＤＴＭＰ的剂量大于人用量的３０倍时，用药后第１天和第７天，动物的白细胞和血小板计数均有降低（Ｐ＜０．０５），但１６天以后恢复到正常。７天和３０天时，９３例患者的血色素、白细胞、淋巴细胞计数与治疗前比较，均无显著性差异（Ｐ＞０．０５）。７天时血小板有减少，３０天以后已恢复到正常。结论：按３７ＭＢｑ／ｋｇ的剂量注射人体，１５３Ｓｍ－ＥＤＴＭＰ对患者的血细胞（主要是血小板）有轻微影响，但１月以后可恢复到正常。使用比较安全。

Purpose:In order to explore the influence of radiopharmaceutical153SmEDTMP on blood cell counts of animal and patients with bone tumor.Methods:The animal models were established by mice,rats and rabbits.The EDTMP doses administered mice are 2000 times as large as doses of 50kg normal human.The153SmEDTMP administered rats,rabbits are 30 times,75 times more than that human,respectively.After that,the Hb,WBC and platelets were detected in various times.153SmEDTMP 37MBq/kg,the blood cell counts were examined.Results:The chemical toxicity of EDTMP in mice was not found.1 day and 7 days administered153SmEDTMP,the counts of WBC and platelets of rats,rabbits were decreased(P<005) respectively.16 days later,its returned to normal levels.After 7 and 30 days received153SmEDTMP(37MBq/kg),there are not significant difference(P>005) in counts of HB、WBC and lymph cell of 93 patients with bone tumor,comparing with control volume.There are significant difference(005>P>001) in platelets of 93 patients at 7 days,30 days later,its returned to normal levels.Conclusions:There are slight influence of radiopharmaceutical153SmEDTMP on blood cell counts(especially platelets) of patients with bone tumor,after 30 days it returned to normal levels.153SmEDTMP has proven to be a safe.