硬化剂对小型香猪甲状腺内分泌功能和组织结构的影响研究

AN EXPERIMENTAL STUDY ON THE THYROID OF SMALL SIZE PERFUME PIG BY INJECTION OF 5% SODIUM MORRHUATE

探讨硬化剂对小型香猪甲状腺组织病理和内分泌功能的影响。方法：５％的鱼肝油酸钠注射于小型香猪甲状腺内，使其硬化达９０％以上时，观察小香猪甲状腺在不同时间组织病理变化和内分泌功能变化。结果：①硬化剂剂量与硬化体积呈线性相关，Ｙ＝１．５Ｘ，②注射硬化剂后甲状腺有明显萎缩，滤泡塌陷，胶质浓缩，变性坏死，纤维结缔组织增生，③注射硬化剂后内分泌功能明显下降。结论：小型香猪甲状腺注射硬化剂后可相当于手术切除部分甲状腺组织。

bjectives:To study the action of sclerosing agent on the thyroid tissues and endocrine functions of smallsize perfume pig. Methods: 5% sodium morrhuate was injected to the thyroid of smallsize perfume pig, causing the thyorid sclerosed more than 90%, and the pathological changes of the tissue and endocrine functions of the thyroid in different time were observed. Results: ①The dose of sclerosing agent and size of sclerosis showed good linearity; ②The thyroids of all animals tested were distinctively atrophic follicular cells collapsed, colloid concentrated, followed by denatured necrosis and fibrous tissue proliferation, ③The endocrine function of the thyroid was distinctively dropping. Conclusions: Injection sclerosing agent to the thyroid of smallsize perfume pig equals to partial section of the thyroid. It may be a new way to treat hyperthyroidism in the clinic.