幽门螺杆菌相关性溃疡的治疗-抗酸和抗菌疗法的对比观察

TREATMENT OF PEPTIC ULCER ASSOCIATED WITH HELICOBACTER PYLERIDIS—COMPARATIVE STUDY BY ANTIACID AND ANTIBACTERIAL METHODS

目的：探讨适合基层Ｈｐ阳性的消化性溃疡的治疗方法。方法：４５例符合条件的病人随机分成三个治疗组：（１）Ｒ组单用雷尼替丁，（２）ＡＭ组羟氨苄青霉素与甲硝唑，（３）ＲＡＭ组雷尼替丁、羟氨苄青霉素与甲硝唑。三组疗程均为２周，疗程结束后６周复查胃镜、尿素酶试验、病理切片染色查Ｈｐ。结果：三组溃疡愈合无显著性差异。但在ＨＰ根除率方面，ＡＭ组（８７．５％）ＲＡＭ组（８５．７％）均优于Ｒ组（２６．６７％），且无明显副作用。结论：单用雷尼替丁对ＨＰ根除无明显作用，合用两种抗生素有较理想的溃疡愈合率和ＨＰ根除率。

bjective: To study a method for treating peptic ulcer with helicobacter pyleridis(HP) positive patients which may be suitable for county of the lower hospitals. Method: 45 cases of patients with peptic ulcers were randomly divided into three groups: group R, ranitidinum; group AM, amoxicillinum and metronidazonum; group RAM, ranitidinum, amoxicillinum and metronidazonum. The treating course for the three groups all were two weeks and at the sixth week following the ending of the treatment, examinations such as gastroscopy, biopsy for HP and urase test were repeated. Results: There wasnt significant difference in ulcer healing for all the groups but in HPeradicating rate group AM(87.5%) and group RAM(85.7%) were better than that of group R(26.67%), and the treatment didnt show marked side effects. Conclusion: For HPeradicating rate ranitidinum alone didnt show marked effect, but better ulcerhealing rate and HPeradicating rate were seen when the ranitidinum was used in combination with the other one or two antibiotics. It is suggested that ranitidinum used in combination with the mentioned antibiotics is suitable for treating peptic ulcer with HP positive cases.