AT1受体抗体在子痫前期孕妇血清中的分布及临床意义
被引量:1
摘要
子痫前期是妊娠20周以后以高血压、蛋白尿为特征的一种严重的妊娠期特有疾病,是孕产妇及围产儿死亡的主要原因之一。此外,有研究表明,女性在孕期患子痫前期者有增加患上心血管疾病的危险。由于其病因及病理学不十分清楚.因此对该病缺乏足够的防治措施。以往把妊娠高血压疾病的发病归咎于孕产妇的血管病变,胎盘浅着床及孕妇过多的炎症反应,其中血管损伤是该病的典型特点,其作用已达成共识。尽管该病的发病机制还不十分清楚,但越来越多的证据表明:
出处
《中国药物与临床》
CAS
2009年第5期432-433,共2页
Chinese Remedies & Clinics
参考文献11
-
1Redman CW,Sargent IL.Latest advances in understanding preeclampsia.Science,2005,308:1592-1594.
-
2Sibai B,Dekker G,Kupferminc M.Pre-eclampsia.Lancet,2005,365:785-799.
-
3Ness RB,Hubel CA.Risk for coronary artery disease and morbid prceclampsia:a commentary.Ann Epidemiol,2005,15:726-733.
-
4Stepan H,Heihoff-Klose A,Faber R.Reduced antioxidant capacity in second-trimester pregnancies with pathological uterine perfusion.Ultrasound Obstet Gynecol,2004,23:579-583.
-
5Davison JM,Homuth V,Jeyabalan A,et al.New aspects in the pathophysiology of preeclampsia.J Am Soc Nephrol,2004,9:2440-2448.
-
6Xia Y,Wen H,Bobst S,et al.Maternal antoantibodies from prceclamptic patients activate angiotensin receptors on human trophoblast cells.J Soc Gynecol Investig,2003,10:82-93.
-
7Wallukat G,Homuth V,Fischer T,et al.Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.J Clin Invest,1999,103:945-952.
-
8Weinberger MH,Kramer NJ,Petersen LP,et al.Sequential changes in the renin-angiotensin-aidosterone systems and plasma progesterone concentration in normal and abnormal human pregnancy.Perspect Nephrol Hypertens,1976,5:263-269.
-
9AbdAlla S,Lother H,Massiery A,et al.Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotonsin Ⅱ responsiveness.Nat Med,2001,7:1003-1009.
-
10Kyle PM,Buckley D,Kissane J,et al.The angiotensin sensitivity test and lew-dose aspirin are ineffective methods to predict and prevent hypertensive disorders in nulliparous pregnancy.Am J Obstet Gynecol,1995,173:865-872.
二级参考文献5
-
1Hoebeke J. Structural basis of autoimmunity against G protein coupled membrane receptors. Int J Cardiol,1996,54:103-111.
-
2Wallukat G, Homuth Ⅴ, Fischer T, et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest,1999,103:945-952.
-
3Dechend R, Homuth Ⅴ, Wallukat G, et al. AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation, 2000,101:2382-2387.
-
4AbdAlla S, Lother H, el Massiery A, et al. Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin Ⅱ responsiveness. Nat Med, 2001,7:1003-1009.
-
5魏宇淼,廖玉华,王敏,董继华,王朝晖,程龙献.抗血管紧张素Ⅱ受体1型和α_1-肾上腺素受体自身抗体在高血压患者检测结果分析[J].中华心血管病杂志,2002,30(6):321-324. 被引量:20
同被引文献11
-
1侯秀红,李东红,李怡,赵宏喜,张春利,黄亮,姚元庆.跨膜型血管内皮生长因子受体1在子痫前期患者胎盘组织中的表达及其意义[J].中华妇产科杂志,2006,41(11):736-739. 被引量:1
-
2Redman CWG,Sargent IL. Latest advance in understanding preeclampsia. Science, 2005,308 (5728) : 1592-1594.
-
3Sibai B,Dekker G,Kupherming M. Pre-eclampsia. Lancet, 2005,365(9461 ) :785-799.
-
4Chedraui P, Lockwood CJ,Schatz F, et al. Increased plasma soluble fms-like tyrosine kinase 1 and endoglin levels in pregnancies complicated with preeclampsia. Matern Fetal Neonatal Med, 2009,6:1-6.
-
5Shama A,Satyam A,Shama JB. Leptin,IL-10 and inflammatory markers in pre-eelamptie,nomotensive pregnant and healthy non-pregnant women. Am J Reprod Immunol,2007,58 ( 1 ) : 21 - 30.
-
6Seolh J,Oh M J, Lee K J, et al. Urinary angiogenie factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol,2004,191(6) : 14.
-
7Muy-Rivera M, Vadachkoria S, Woelk GB, et al. Maternal plasma VEGF, sVEGF-RI,and PIGF concentrations in preeclamptie and nomotensive pregnant Zimbabwean women. Physiol Res,2005,54 (6) :611-622.
-
8Merviel P, Carbillon L, Challier JC,et al. Pathophysiology of preeclampsia: links with implantation disorders. Eur J Obstet Gynecol Reprod Biol, 2004,115 (2) : 134-147.
-
9Naicker T, Khedum SM,Moodley J,et al. Quantitative analysis of trophoblast invasion in preeclampsia. Acta Obstet Gynecol Scand, 2003,82 (8) : 722-729.
-
10徐匆,刘伟.子痫前期胎盘学研究进展[J].中国实用妇科与产科杂志,2009,25(4):300-303. 被引量:9
-
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-
2朱孔艳.硫酸镁联合硝苯地平治疗妊娠高血压疾病的疗效观察[J].中国卫生标准管理,2016,7(10):122-123. 被引量:1
-
3刘精霞.呼吸内科护理中重症患者的护理效果观察[J].中国社区医师(医学专业),2012,14(17):336-337. 被引量:47
-
4张芳,徐春蕾,王筱曚,邱郑.基于士的宁和马钱子碱为主要活性成分的马钱子抗肿瘤活性研究[J].中华中医药杂志,2014,29(11):3491-3493. 被引量:6
-
5陈凤英,章力行.高效液相色谱法测定孕妇血清犬尿氨酸的含量[J].中国医院药学杂志,2003,23(3):188-188. 被引量:5
-
6马素霞.妊高征的护理[J].医药论坛杂志,2003,24(15):77-77. 被引量:2
-
7张玉.浅析妊娠期高血压患者的临床观察与护理对策[J].医学美学美容(中旬刊),2014,23(11):687-687.
-
8余俊.重度妊高征28例护理体会[J].现代中西医结合杂志,2002,11(10):980-980.
-
9郝良巧.骨质疏松症患者健康教育需求调查分析[J].齐鲁护理杂志,2007,13(1). 被引量:3
-
10张玉琪.妊高征的药物治疗[J].天津药学,2011,23(1):62-64. 被引量:4